Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture
Figure 6
Effects of STZ on p38 kinase and the ion channel TRPV1 are counteracted by EA. Representative Western blot of three samples for each experimental group is presented in each panel, together with data from a densitometry analysis of three separate gel/blot runs (). As revealed by Western blot densitometry, the TRPV1 (a) underwent significant increase, compared to controls in rat DRGs four weeks after diabetes induction. EA normalizes this effect, restoring basal TRPV1 levels. STZ also induced a significant increase in the total kinase p38 and in the -p38 (b). EA in diabetic animals was able to counteract the STZ effects on p38 expression activation, restoring basal levels of both total and phosphorylated p38. Data presented in panel (a) and (b) are obtained after normalization with GAPDH band integrated optical density. Data are expressed as % of controls mean () SD. * versus control group. # versus STZ group.
