Table 1: Six metabolites of YZP detected in vivo from the previous experiment.

No.RT (min)[M + H]+FormulaMetabolite nameFormula changeParent compoundSource

M14.1880342.1333C19H19NO5Demethylation, hydrogenation−CH2+H2ProtopinePlasma
M29.08278342.1691C20H23NO4Demethylation−CH2TetrahydropalmatinePlasma
M310.6147342.1695C20H23NO4Demethylation−CH2TetrahydropalmatinePlasma, CSF
M421.8366301.0715C16H12O6Methylene to ketone+O–H2OxypeucedaninPlasma
M55.21887326.1384C19H19NO4Demethylation−CH2TetrahydroberberinePlasma, CSF
M68.0093326.1386C19H19NO4Demethylation−CH2TetrahydroberberinePlasma

CSF: cerebrospinal fluid.