Cerebrospinal Fluid Pharmacology: An Improved Pharmacology Approach for Chinese Herbal Medicine Research

Table 1

Brief introduction of mainly experimental techniques in CSFP.

Technique	Application fields	Advantage	Literatures
Percutaneous puncture	The acquisition of CSF containing drugs in rabbit and rat	Effectively avoid injuring the medulla oblongata, and blood vessel, significantly increase the rate of success in drawing CSF	[49]
Foramen magnum puncture	The acquisition of CSF containing drugs in SD rats	More visual and convenient to operate, causing less injury and complications and possessesing high rate of success	[50, 51]
Using microinjector via spinal dura mater puncture under direct vision	The acquisition of CSF containing drugs in SD rats	A fast, convenient, and clean technique for collecting CSF, increase the collection volume of CSF	[52]
The optimization to acquisition time of CSF containing drugs	The acquisition of CSF containing drugs in SD rats	Obtain optimal CSF containing drug	[43, 47, 48]
Analysis on transitional composition of drug in cerebrospinal fluid	Clarify main effective constituents	Convenient to clarify the true active ingredients	[69, 70]
Analysis on transitional composition association of drug in cerebrospinal fluid	Verify constituents or drug association and perfect quality standard	Simplify the complexity of constituents or drug and find out potential association	[75]