Review Article
Cerebrospinal Fluid Pharmacology: An Improved Pharmacology Approach for Chinese Herbal Medicine Research
Table 1
Brief introduction of mainly experimental techniques in CSFP.
| Technique | Application fields | Advantage | Literatures |
| Percutaneous puncture | The acquisition of CSF containing drugs in rabbit and rat | Effectively avoid injuring the medulla oblongata, and blood vessel, significantly increase the rate of success in drawing CSF | [49] |
| Foramen magnum puncture | The acquisition of CSF containing drugs in SD rats | More visual and convenient to operate, causing less injury and complications and possessesing high rate of success | [50, 51] |
| Using microinjector via spinal dura mater puncture under direct vision | The acquisition of CSF containing drugs in SD rats | A fast, convenient, and clean technique for collecting CSF, increase the collection volume of CSF | [52] |
| The optimization to acquisition time of CSF containing drugs | The acquisition of CSF containing drugs in SD rats | Obtain optimal CSF containing drug | [43, 47, 48] |
| Analysis on transitional composition of drug in cerebrospinal fluid | Clarify main effective constituents | Convenient to clarify the true active ingredients | [69, 70] |
| Analysis on transitional composition association of drug in cerebrospinal fluid | Verify constituents or drug association and perfect quality standard | Simplify the complexity of constituents or drug and find out potential association | [75] |
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