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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 681304, 10 pages
http://dx.doi.org/10.1155/2013/681304
Review Article

Lavender and the Nervous System

1Shefa Neuroscience Research Center, Tehran 1996835911, Iran
2Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, 48149 Münster, Germany
3Razavi Neuroscience Research Center, Mashhad 9198613636, Iran
4Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany
5Institut für Physiologie I, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany
6Department of Neurology, 48149 Münster, Germany

Received 4 September 2012; Revised 29 December 2012; Accepted 17 February 2013

Academic Editor: Mark Moss

Copyright © 2013 Peir Hossein Koulivand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. M. A. Cavanagh and J. M. Wilkinson, “Biological activities of lavender essential oil,” Phytotherapy Research, vol. 16, no. 4, pp. 301–308, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Woronuk, Z. Demissie, M. Rheault, and S. Mahmoud, “Biosynthesis and therapeutic properties of lavandula essential oil constituents,” Planta Medica, vol. 77, no. 1, pp. 7–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Prashar, I. C. Locke, and C. S. Evans, “Cytotoxicity of lavender oil and its major components to human skin cells,” Cell Proliferation, vol. 37, no. 3, pp. 221–229, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. W. N. Setzer, “Essential oils and anxiolytic aromatherapy,” Natural Product Communications, vol. 4, no. 9, pp. 1305–1316, 2009. View at Scopus
  5. P. Sasannejad, M. Saeedi, A. Shoeibi, et al., “Lavender essential oil in the treatment of migraine headache: a placebo-controlled clinical trial,” European Journal of Neurology, vol. 67, no. 5, pp. 288–291, 2012. View at Publisher · View at Google Scholar
  6. F. Xu, K. Uebaba, H. Ogawa et al., “Pharmaco-physio-psychologic effect of ayurvedic oil-dripping treatment using an essential oil from Lavendula angustifolia,” Journal of Alternative and Complementary Medicine, vol. 14, no. 8, pp. 947–956, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Morris, “The effects of lavender (Lavendula angustifolium) baths on psychological well-being: two exploratory randomized controls trials,” Complementary Therapies in Medicine, vol. 10, no. 4, pp. 223–228, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Jager, G. Buchbauer, L. Jirovetz, and M. Fritzer, “Percutaneous absorbtion of lavender oil from a massage oil,” Journal of the Society of Cosmetic Chemists, vol. 43, pp. 49–54, 1992.
  9. N. Vakili and A. Gorji, “Psychiatry and psychology in medieval Persia,” Journal of Clinical Psychiatry, vol. 67, no. 12, pp. 1862–1869, 2006. View at Scopus
  10. A. Gorji and M. Khaleghi Ghadiri, “History of epilepsy in Medieval Iranian medicine,” Neuroscience and Biobehavioral Reviews, vol. 25, no. 5, pp. 455–461, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Gorji and M. K. Ghadiri, “History of headache in medieval Persian medicine,” Lancet Neurology, vol. 1, no. 8, pp. 510–515, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Gorji, “Pharmacological treatment of headache using traditional persian medicine,” Trends in Pharmacological Sciences, vol. 24, no. 7, pp. 331–334, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. S. S. Denner, “Lavandula angustifolia miller: english lavender,” Holistic Nursing Practice, vol. 23, no. 1, pp. 57–64, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. H. Gilani, N. Aziz, M. A. Khan et al., “Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L,” Journal of Ethnopharmacology, vol. 71, no. 1-2, pp. 161–167, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Umezu, “Behavioral effects of plant-derived essential oils in the Geller type conflict test in mice,” Japanese Journal of Pharmacology, vol. 83, no. 2, pp. 150–153, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Hritcu, O. Cioanca, and M. Hancianu, “Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats,” Phytomedicine, vol. 19, no. 6, pp. 529–534, 2012. View at Publisher · View at Google Scholar
  17. T. Umezu, K. Nagano, H. Ito, K. Kosakai, M. Sakaniwa, and M. Morita, “Anticonflict effects of lavender oil and identification of its active constituents,” Pharmacology Biochemistry and Behavior, vol. 85, no. 4, pp. 713–721, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Shaw, J. M. Annett, B. Doherty, and J. C. Leslie, “Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats,” Phytomedicine, vol. 14, no. 9, pp. 613–620, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. B. F. Bradley, N. J. Starkey, S. L. Brown, and R. W. Lea, “Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze,” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 517–525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. V. M. Linck, A. L. da Silva, M. Figueiró, E. B. Caramão, P. R. H. Moreno, and E. Elisabetsky, “Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice,” Phytomedicine, vol. 17, no. 8-9, pp. 679–683, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Ghelardini, N. Galeotti, G. Salvatore, and G. Mazzanti, “Local anaesthetic activity of the essential oil of Lavandula angustifolia,” Planta Medica, vol. 65, no. 8, pp. 700–703, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Alnamer, K. Alaoui, H. Bouidida el, et al., “Sedative and hypnotic activities of the methanolic and aqueous extracts of Lavandula officinalis from Morocco,” Advances in Pharmacological Sciences, vol. 2012, Article ID 270824, 5 pages, 2012. View at Publisher · View at Google Scholar
  23. W. C. Lim, J. M. Seo, C. I. Lee, H. B. Pyo, and B. C. Lee, “Stimulative and sedative effects of essential oils upon inhalation in mice,” Archives of Pharmacal Research, vol. 28, no. 7, pp. 770–774, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Buchbauer, L. Jirovetz, W. Jäger, H. Dietrich, and C. Plank, “Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation,” Zeitschrift fur Naturforschung, vol. 46, no. 11-12, pp. 1067–1072, 1991. View at Scopus
  25. T. Sakurada, H. Kuwahata, S. Katsuyama et al., “Chapter 18 intraplantar injection of Bergamot essential oil into the mouse hindpaw. Effects on capsaicin-induced nociceptive behaviors,” International Review of Neurobiology, vol. 85, pp. 237–248, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Barocelli, F. Calcina, M. Chiavarini et al., “Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "grosso" essential oil,” Life Sciences, vol. 76, no. 2, pp. 213–223, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Hartman and J. C. Coetzee, “Two US practitioners' experience of using essential oils for wound care,” Journal of Wound Care, vol. 11, no. 8, pp. 317–320, 2002. View at Scopus
  28. M. S. Kashani, M. R. Tavirani, S. A. Talaei, and M. Salami, “Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease,” Neuroscience Bulletin, vol. 27, no. 2, pp. 99–106, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Guillmain, A. Rousseau, and P. Delaveau, “Effets neurodepresseurs de l’huile essentielle de lavandula augustifolia Mill,” Annales Pharmaceutiques, vol. 47, pp. 337–343, 1989.
  30. A. Arzi, M. Ahamehe, and S. Sarahroodi, “Effect of hydroalcoholic extract of Lavandula officinalis on nicotine-induced convulsion in mice,” Pakistan Journal of Biological Sciences, vol. 14, no. 11, pp. 634–640, 2011. View at Publisher · View at Google Scholar
  31. M. Lis-Balchin and S. Hart, “Studies on the mode of action of the essential oil of lavender (Lavandula angustifolia P. Miller),” Phytotherapy Research, vol. 13, pp. 540–542, 1999. View at Publisher · View at Google Scholar
  32. S. Atanossova-Shopova and K. S. Roussinov, “On certain central neurolotropic effects of lavender essential oil,” Bulletin of the Institute of Physiology, vol. 8, pp. 69–76, 1970.
  33. K. Yamada, Y. Mimaki, and Y. Sashida, “Anticonvulsive effects of inhaling lavender oil vapour,” Biological and Pharmaceutical Bulletin, vol. 17, no. 2, pp. 359–360, 1994. View at Scopus
  34. E. Elisabetsky, L. F. S. Brum, and D. O. Souza, “Anticonvulsant properties of linalool in glutamate-related seizure models,” Phytomedicine, vol. 6, no. 2, pp. 107–113, 1999. View at Scopus
  35. D. P. de Sousa, F. F. F. Nóbrega, C. C. M. P. Santos, and R. N. de Almeida, “Anticonvulsant activity of the linalool enantiomers and racemate: investigation of chiral influence,” Natural Product Communications, vol. 5, no. 12, pp. 1847–1851, 2010. View at Scopus
  36. L. F. Silva Brum, E. Elisabetsky, and D. Souza, “Effects of linalool on [3H] MK801 and [3H] muscimol binding in mouse cortical membranes,” Phytotherapy Research, vol. 15, no. 5, pp. 422–425, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. M. E. Büyükokuroğlu, A. Gepdiremen, A. Hacimüftüoğlu, and M. Oktay, “The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups,” Journal of Ethnopharmacology, vol. 84, pp. 91–94, 2003. View at Publisher · View at Google Scholar
  38. D. Wang, X. Yuan, T. Liu, et al., “Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice,” Molecules, vol. 17, no. 8, pp. 9803–9817, 2012. View at Publisher · View at Google Scholar
  39. M. Y. Huang, M. H. Liao, Y. K. Wang, et al., “Effect of lavender essential oil on LPS-stimulated inflammation,” American Journal of Chinese Medicine, vol. 40, no. 4, pp. 845–859, 2012. View at Publisher · View at Google Scholar
  40. S. M. Salah and A. K. Jäger, “Screening of traditionally used Lebanese herbs for neurological activities,” Journal of Ethnopharmacology, vol. 97, no. 1, pp. 145–149, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. N. S. L. Perry, P. J. Houghton, A. Theobald, P. Jenner, and E. K. Perry, “In-vitro inhibition of human erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes,” Journal of Pharmacy and Pharmacology, vol. 52, no. 7, pp. 895–902, 2000. View at Scopus
  42. N. S. L. Perry, C. Bollen, E. K. Perry, and C. Ballard, “Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial,” Pharmacology Biochemistry and Behavior, vol. 75, no. 3, pp. 651–659, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Savelev, E. Okello, N. S. L. Perry, R. M. Wilkins, and E. K. Perry, “Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil,” Pharmacology Biochemistry and Behavior, vol. 75, no. 3, pp. 661–668, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Re, S. Barocci, S. Sonnino et al., “Linalool modifies the nicotinic receptor-ion channel kinetics at the mouse neuromuscular junction,” Pharmacological Research, vol. 42, no. 2, pp. 177–181, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Kim, M. Kim, H. Kim, and K. Kim, “Effect of lavender oil on motor function and dopamine receptor expression in the olfactory bulb of mice,” Journal of Ethnopharmacology, vol. 125, no. 1, pp. 31–35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Aoshima and K. Hamamoto, “Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid,” Bioscience, Biotechnology and Biochemistry, vol. 63, no. 4, pp. 743–748, 1999. View at Scopus
  47. H. M. Kim and S. H. Cho, “Lavender oil inhibits immediate-type allergic reaction in mice and rats,” Journal of Pharmacy and Pharmacology, vol. 51, no. 2, pp. 221–226, 1999. View at Scopus
  48. J. Shen, A. Niijima, M. Tanida, Y. Horii, K. Maeda, and K. Nagai, “Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats,” Neuroscience Letters, vol. 383, no. 1-2, pp. 188–193, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Tanida, A. Yamatodani, A. Niijima, J. Shen, T. Todo, and K. Nagai, “Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice,” Neuroscience Letters, vol. 413, no. 2, pp. 177–182, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Shen, A. Niijima, M. Tanida, Y. Horii, T. Nakamura, and K. Nagai, “Mechanism of changes induced in plasma glycerol by scent stimulation with grapefruit and lavender essential oils,” Neuroscience Letters, vol. 416, no. 3, pp. 241–246, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Kasper, M. Gastpar, W. E. Müller et al., “Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder—evidence from clinical trials,” Wiener Medizinische Wochenschrift, vol. 160, no. 21-22, pp. 547–556, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. S. Kasper, M. Gastpar, W. E. Müller et al., “Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial,” International Clinical Psychopharmacology, vol. 25, no. 5, pp. 277–287, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. H. Woelk and S. Schläfke, “A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder,” Phytomedicine, vol. 17, no. 2, pp. 94–99, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. C. Dunn, J. Sleep, and D. Collett, “Sensing an improvement: an experimental study to evaluate the use of aromatherapy, massage and periods of rest in an intensive care unit,” Journal of advanced nursing, vol. 21, no. 1, pp. 34–40, 1995. View at Scopus
  55. T. Itai, H. Amayasu, M. Kuribayashi et al., “Psychological effects of aromatherapy on chronic hemodialysis patients,” Psychiatry and Clinical Neurosciences, vol. 54, no. 4, pp. 393–397, 2000. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Walsh and C. Wilson, “Complementary therapies in long-stay neurology in-patient settings,” Nursing Standard, vol. 13, no. 32, pp. 32–35, 1999. View at Scopus
  57. P. Conrad and C. Adams, “The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman—a pilot study,” Complementary Therapies in Clinical Practice, vol. 18, no. 3, pp. 164–168, 2012. View at Publisher · View at Google Scholar
  58. J. Lehrner, G. Marwinski, S. Lehr, P. Johren, and L. Deecke, “Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office,” Physiology and Behavior, vol. 86, no. 1-2, pp. 92–95, 2005. View at Publisher · View at Google Scholar · View at Scopus
  59. M. Kritsidima, T. Newton, and K. Asimakopoulou, “The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial,” Community Dentistry and Oral Epidemiology, vol. 38, no. 1, pp. 83–87, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. R. Braden, S. Reichow, and M. A. Halm, “The use of the essential oil Lavandin to reduce preoperative anxiety in surgical patients,” Journal of Perianesthesia Nursing, vol. 24, no. 6, pp. 348–355, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. B. F. Bradley, S. L. Brown, S. Chu, and R. W. Lea, “Effects of orally administered lavender essential oil on responses to anxiety-provoking film clips,” Human Psychopharmacology, vol. 24, no. 4, pp. 319–330, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Akhondzadeh, L. Kashani, A. Fotouhi et al., “Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 27, no. 1, pp. 123–127, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. X. Duan, M. Tashiro, D. Wu et al., “Autonomic nervous function and localization of cerebral activity during lavender aromatic immersion,” Technology and Health Care, vol. 15, no. 2, pp. 69–78, 2007. View at Scopus
  64. J. Wang, P. J. Eslinger, M. B. Smith, and Q. X. Yang, “Functional magnetic resonance imaging study of human olfaction and normal aging,” Journals of Gerontology A, vol. 60, no. 4, pp. 510–514, 2005. View at Scopus
  65. W. Di Nardo, S. Di Girolamo, A. Galli, G. Meduri, G. Paludetti, and G. de Rossi, “Olfactory function evaluated by SPECT,” American Journal of Rhinology, vol. 14, no. 1, pp. 57–61, 2000. View at Scopus
  66. D. M. Small, J. C. Gerber, Y. E. Mak, and T. Hummel, “Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans,” Neuron, vol. 47, no. 4, pp. 593–605, 2005. View at Publisher · View at Google Scholar · View at Scopus
  67. M. A. Diego, N. A. Jones, T. Field et al., “Aromatherapy positively affects mood, EEG patterns of alertness and math computations,” International Journal of Neuroscience, vol. 96, no. 3-4, pp. 217–224, 1998. View at Scopus
  68. G. D. Jacobs, H. Benson, and R. Friedman, “Topographic EEG mapping of the relaxation response,” Biofeedback and Self-Regulation, vol. 21, no. 2, pp. 121–129, 1996. View at Scopus
  69. W. Sayorwan, V. Siripornpanich, T. Piriyapunyaporn, T. Hongratanaworakit, N. Kotchabhakdi, and N. Ruangrungsi, “The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity,” Journal of the Medical Association of Thailand, vol. 95, pp. 598–606, 2012.
  70. R. Masago, T. Matsuda, Y. Kikuchi et al., “Effects of inhalation of essential oils on EEG activity and sensory evaluation,” Journal of Physiological Anthropology and Applied Human Science, vol. 19, no. 1, pp. 35–42, 2000. View at Scopus
  71. C. Holmes, V. Hopkins, C. Hensford, V. MacLaughlin, D. Wilkinson, and H. Rosenvinge, “Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study,” International Journal of Geriatric Psychiatry, vol. 17, no. 4, pp. 305–308, 2002. View at Publisher · View at Google Scholar · View at Scopus
  72. D. A. Moscovitch, D. L. Santesso, V. Miskovic, et al., “Frontal EEG asymmetry and symptom response to cognitive behavioral therapy in patients with social anxiety disorder,” Biological Psychology, vol. 87, no. 3, pp. 379–385, 2011. View at Publisher · View at Google Scholar
  73. C. Sanders, M. Diego, M. Fernandez, T. Field, M. Hernandez-Reif, and A. Roca, “EEG asymmetry responses to lavender and rosemary aromas in adults and infants,” International Journal of Neuroscience, vol. 112, no. 11, pp. 1305–1320, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. K. Hirokawa, T. Nishimoto, and T. Taniguchi, “Effects of lavender aroma on sleep quality in healthy Japanese students,” Perceptual & Motor Skills, vol. 114, no. 1, pp. 111–122, 2012. View at Publisher · View at Google Scholar
  75. M. Moeini, M. Khadibi, R. Bekhradi, et al., “Effect of aromatherapy on the quality of sleep in ischemic heart disease patients hospitalized in intensive care units of heart hospitals of the Isfahan University of Medical Sciences,” Iranian Journal of Nursing and Midwifery Research, vol. 15, no. 4, pp. 234–239, 2010.
  76. L. W. Chien, S. L. Cheng, and C. F. Liu, “The effect of lavender aromatherapy on autonomic nervous system in midlife women with insomnia,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 740813, 8 pages, 2012. View at Publisher · View at Google Scholar
  77. G. T. Lewith, A. D. Godfrey, and P. Prescott, “A single-blinded, randomized pilot study evaluating the aroma of Lavandula augustifolia as a treatment for mild insomnia,” Journal of Alternative and Complementary Medicine, vol. 11, no. 4, pp. 631–637, 2005. View at Publisher · View at Google Scholar · View at Scopus
  78. C. Graham, “Complementary therapies: in the scent of a good night’s sleep,” Nursing Standard, vol. 9, article 21, 1995.
  79. M. Hardy, M. D. Kirk-Smith, and D. D. Stretch, “Replacement of drug treatment for insomnia by ambient odour,” Lancet, vol. 346, no. 8976, p. 701, 1995. View at Scopus
  80. R. Hudson, “The value of lavender for rest and activity in the elderly patient,” Complementary Therapies in Medicine, vol. 4, no. 1, pp. 52–57, 1996. View at Scopus
  81. T. I. Williams, “Evaluating effects of aromatherapy massage on sleep in children with autism: a pilot study,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 3, pp. 373–377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  82. M. Ching, “Contemporary therapy: aromatherapy in the management of acute pain?” Contemporary Nurse, vol. 8, no. 4, pp. 146–151, 1999. View at Scopus
  83. A. Woolfson and D. Hewitt, “Intensive aromacare,” International Journal of Aromatherapy, vol. 4, no. 2, pp. 12–13, 1992.
  84. D. T. Altaei, “Topical lavender oil for the treatment of recurrent aphthous ulceration,” American Journal of Dentistry, vol. 25, no. 1, pp. 39–43, 2012.
  85. S. Kim, H. J. Kim, J. S. Yeo, et al., “The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers,” Journal of Alternative and Complementary Medicine, vol. 17, no. 9, pp. 823–826, 2011. View at Publisher · View at Google Scholar
  86. M. C. Ou, T. F. Hsu, A. C. Lai, et al., “Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial,” Journal of Obstetrics and Gynaecology Research, vol. 38, no. 5, pp. 817–822, 2012. View at Publisher · View at Google Scholar
  87. N. Hadi and A. A. Hanid, “Lavender essence for post-cesarean pain,” Pakistan Journal of Biological Sciences, vol. 14, no. 11, pp. 664–667, 2011. View at Publisher · View at Google Scholar
  88. K. Vakilian, M. Atarha, R. Bekhradi, and R. Chaman, “Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial,” Complementary Therapies in Clinical Practice, vol. 17, no. 1, pp. 50–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  89. F. Sheikhan, F. Jahdi, E. M. Khoei, et al., “Episiotomy pain relief: use of Lavender oil essence in primiparous Iranian women,” Complementary Therapies in Clinical Practice, vol. 18, no. 1, pp. 66–70, 2012. View at Publisher · View at Google Scholar
  90. A. Dale and S. Cornwell, “The role of lavender oil in relieving perineal discomfort following childbirth: a blind randomized clinical trial,” Journal of Advanced Nursing, vol. 19, no. 1, pp. 89–96, 1994. View at Scopus
  91. J. T. Kim, M. Wajda, G. Cuff et al., “Evaluation of aromatherapy in treating postoperative pain: pilot study,” Pain Practice, vol. 6, no. 4, pp. 273–277, 2006. View at Publisher · View at Google Scholar · View at Scopus
  92. J. T. Kim, C. J. Ren, G. A. Fielding et al., “Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding,” Obesity Surgery, vol. 17, no. 7, pp. 920–925, 2007. View at Publisher · View at Google Scholar · View at Scopus
  93. L. D. Grunebaum, J. Murdock, M. P. Castanedo-Tardan, and L. S. Baumann, “Effects of lavender olfactory input on cosmetic procedures,” Journal of Cosmetic Dermatology, vol. 10, no. 2, pp. 89–93, 2011. View at Publisher · View at Google Scholar · View at Scopus
  94. Y. B. Yip and S. H. M. Tse, “The effectiveness of relaxation acupoint stimulation and acupressure with aromatic lavender essential oil for non-specific low back pain in Hong Kong: a randomised controlled trial,” Complementary Therapies in Medicine, vol. 12, no. 1, pp. 28–37, 2004. View at Publisher · View at Google Scholar · View at Scopus
  95. Y. B. Yip and S. H. M. Tse, “An experimental study on the effectiveness of acupressure with aromatic lavender essential oil for sub-acute, non-specific neck pain in Hong Kong,” Complementary Therapies in Clinical Practice, vol. 12, no. 1, pp. 18–26, 2006. View at Publisher · View at Google Scholar · View at Scopus
  96. M. H. Hur, Y. S. Yang, and M. S. Lee, “Aromatherapy massage affects menopausal symptoms in Korean climacteric women: a pilot-controlled clinical trial,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 3, pp. 325–328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  97. M. P. Pase, J. Kean, J. Sarris, C. Neale, A. B. Scholey, and C. Stough, “The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials,” Journal of Alternative Complementary Medicine, vol. 18, no. 7, pp. 647–652, 2012. View at Publisher · View at Google Scholar
  98. M. Moss, J. Cook, K. Wesnes, and P. Duckett, “Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults,” International Journal of Neuroscience, vol. 113, no. 1, pp. 15–38, 2003. View at Publisher · View at Google Scholar · View at Scopus
  99. P. Tysoe, “The effect on staff of essential oil burners in extended care settings,” International Journal of Nursing Practice, vol. 6, no. 2, pp. 110–112, 2000. View at Scopus
  100. D. Jimbo, Y. Kimura, M. Taniguchi, M. Inoue, and K. Urakami, “Effect of aromatherapy on patients with Alzheimer's disease,” Psychogeriatrics, vol. 9, no. 4, pp. 173–179, 2009. View at Publisher · View at Google Scholar · View at Scopus
  101. J. Degel and E. P. Köster, “Odors: implicit memory and performance effects,” Chemical Senses, vol. 24, no. 3, pp. 317–325, 1999. View at Publisher · View at Google Scholar
  102. H. W. Ludvigson and T. R. Rottman, “Effects of ambient odors of lavender and cloves on cognition, memory, affect and mood,” Chemical Senses, vol. 14, no. 4, pp. 525–536, 1989. View at Scopus
  103. B. Uehleke, S. Schaper, A. Dienel, S. Schlaefke, and R. Stange, “Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder,” Phytomedicine, vol. 19, no. 8-9, pp. 665–671, 2012. View at Publisher · View at Google Scholar
  104. D. V. Henley, N. Lipson, K. S. Korach, and C. A. Bloch, “Prepubertal gynecomastia linked to lavender and tea tree oils,” New England Journal of Medicine, vol. 356, no. 5, pp. 479–485, 2007. View at Publisher · View at Google Scholar · View at Scopus
  105. F. M. Brandão, “Occupational allergy to lavender oil,” Contact Dermatitis, vol. 15, no. 4, pp. 249–250, 1986. View at Publisher · View at Google Scholar
  106. M. Sugiura, R. Hayakawa, Y. Kato, K. Sugiura, and R. Hashimoto, “Results of patch testing with lavender oil in Japan,” Contact Dermatitis, vol. 43, no. 3, pp. 157–160, 2000. View at Publisher · View at Google Scholar · View at Scopus
  107. H. Woelk and S. Schläfke, “A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder,” Phytomedicine, vol. 17, no. 2, pp. 94–99, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. E. Ernst, “Herbal medicinal products during pregnancy: are they safe?” British Journal of Gynecology, vol. 109, no. 3, pp. 227–235, 2002. View at Publisher · View at Google Scholar · View at Scopus
  109. R. Perry, R. Terry, L. K. Watson, and E. Ernst, “Is lavender an anxiolytic drug? A systematic review of randomised clinical trials,” Phytomedicine, vol. 19, pp. 825–835, 2012. View at Publisher · View at Google Scholar
  110. A. V. Dwyer, D. L. Whitten, and J. A. Hawrelak, “Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review,” Alternative Medicine Review, vol. 16, no. 1, pp. 40–49, 2011. View at Scopus