Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata
Figure 3
Effects of MAB on H. pylori (Hp) CagA-mediated NF-κB activation and p65 nuclear translocation. The levels of NF-κB luciferase activity (a) and nuclear p65 (b) were determined in the cell lysates as described in Section 2. Proliferating cell nuclear antigen (PCNA) was used as a loading control for the nuclear fraction of cell lysates. Results are shown as mean values ± standard deviations from 3 independent experiments. Statistical significance was determined using the Student’s -test when compared to the mock control. ** was considered as statistically significant. WT, wild-type Hp; ΔCagA, cagA mutant Hp.
