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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 682418, 12 pages
Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan
2Institute of Biochemical Sciences and Technology, Chaoyang University of Technology, Taichung 41349, Taiwan
3Department of Biochemistry and Molecular Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA
4Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
5Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
7Department of Microbiology and Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
Received 11 October 2012; Accepted 23 December 2012
Academic Editor: Mohd Roslan Sulaiman
Copyright © 2013 Chun-Jung Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- B. Marshall, “Helicobacter pylori: 20 years on,” Clinical Medicine, vol. 2, no. 2, pp. 147–152, 2002.
- A. Covacci, J. L. Telford, G. Del Giudice, J. Parsonnet, and R. Rappuoli, “Helicobacter pylori virulence and genetic geography,” Science, vol. 284, no. 5418, pp. 1328–1333, 1999.
- S. Odenbreit, J. Püls, B. Sedlmaier, E. Gerland, W. Fischer, and R. Haas, “Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion,” Science, vol. 287, no. 5457, pp. 1497–1500, 2000.
- M. Hatakeyama, “Helicobacter pylori and gastric carcinogenesis,” Journal of Gastroenterology, vol. 44, no. 4, pp. 239–248, 2009.
- S. Brandt, T. Kwok, R. Hartig, W. König, and S. Backert, “NF-κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 26, pp. 9300–9305, 2005.
- H. Higashi, R. Tsutsumi, S. Muto et al., “SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein,” Science, vol. 295, no. 5555, pp. 683–686, 2002.
- H. Mimuro, T. Suzuki, J. Tanaka, M. Asahi, R. Haas, and C. Sasakawa, “Grb2 is a key mediator of Helicobacter pylori CagA protein activities,” Molecular Cell, vol. 10, no. 4, pp. 745–755, 2002.
- N. Ohnishi, H. Yuasa, S. Tanaka et al., “Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 3, pp. 1003–1008, 2008.
- C. H. Lai, Y. C. Chang, S. Y. Du et al., “Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells,” Infection and Immunity, vol. 76, no. 7, pp. 3293–3303, 2008.
- C. H. Lai, H. J. Wang, Y. C. Chang et al., “Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain,” FEMS Microbiology Letters, vol. 323, no. 2, pp. 155–163, 2011.
- N. Murata-Kamiya, K. Kikuchi, T. Hayashi, H. Higashi, and M. Hatakeyama, “Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein,” Cell Host and Microbe, vol. 7, no. 5, pp. 399–411, 2010.
- F. Lafont and F. G. van der Goot, “Bacterial invasion via lipid rafts,” Cellular Microbiology, vol. 7, no. 5, pp. 613–620, 2005.
- H. J. Wang, W. C. Cheng, H. H. Cheng, C. H. Lai, and W. C. Wang, “Helicobacter pylori cholesteryl glucosides interfere with host membrane phase and affect type IV secretion system function during infection in AGS cells,” Molecular Microbiology, vol. 83, no. 1, pp. 67–84, 2012.
- J. M. Vitor and F. F. Vale, “Alternative therapies for Helicobacter pylori: probiotics and phytomedicine,” FEMS Immunology and Medicinal Microbiology, vol. 63, no. 2, pp. 153–164, 2011.
- Y. M. Tzeng and M. Geethangili, “Review of pharmacological effects of Antrodia camphorata and its bioactive compounds,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 212641, 17 pages, 2011.
- C. T. Yeh, Y. K. Rao, C. J. Yao et al., “Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells,” Cancer Letters, vol. 285, no. 1, pp. 73–79, 2009.
- M. Geethangili, S. H. Fang, C. H. Lai, Y. K. Rao, H. M. Lien, and Y. M. Tzeng, “Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation,” Food Chemistry, vol. 119, no. 1, pp. 149–153, 2010.
- D. Y. Lu, H. C. Chen, M. S. Yang et al., “Ceramide and Toll-like receptor 4 are mobilized into membrane rafts in response to Helicobacter pylori infection in gastric epithelial cells,” Infection and Immunity, vol. 80, no. 5, pp. 1823–1833.
- W. C. Lin, H. F. Tsai, S. H. Kuo et al., “Translocation of Helicobacter pylori CagA into human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma,” Cancer Research, vol. 70, no. 14, pp. 5740–5748, 2010.
- S. Bolte and F. P. Cordelières, “A guided tour into subcellular colocalization analysis in light microscopy,” Journal of Microscopy, vol. 224, no. 3, pp. 213–232, 2006.
- C. S. Chang, J. F. Liu, H. J. Lin et al., “Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells,” European Journal of Medicinal Chemistry, vol. 48, pp. 244–254, 2012.
- K. J. McLean, P. Lafite, C. Levy et al., “The structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection,” Journal of Biological Chemistry, vol. 284, no. 51, pp. 35524–35533, 2009.
- P. Gouet, E. Courcelle, D. I. Stuart, and F. Métoz, “ESPript: analysis of multiple sequence alignments in PostScript,” Bioinformatics, vol. 15, no. 4, pp. 305–308, 1999.
- K. C. Hsu, Y. F. Chen, S. R. Lin, and J. M. Yang, “Igemdock: a graphical environment of enhancing gemdock using pharmacological interactions and post-screening analysis,” BMC Bioinformatics, vol. 12, no. 1, article S33, 2011.
- A. Lamb, X. D. Yang, Y. H. N. Tsang et al., “Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination,” EMBO Reports, vol. 10, no. 11, pp. 1242–1249, 2009.
- S. Backert and M. Selbach, “Role of type IV secretion in Helicobacter pylori pathogenesis,” Cellular Microbiology, vol. 10, no. 8, pp. 1573–1581, 2008.
- M. Hatakeyama, “SagA of CagA in Helicobacter pylori pathogenesis,” Current Opinion in Microbiology, vol. 11, no. 1, pp. 30–37, 2008.
- C. L. de Melo, M. G. R. Queiroz, A. C. V. Arruda Filho et al., “Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet,” Journal of Agricultural and Food Chemistry, vol. 57, no. 19, pp. 8776–8781, 2009.
- J. Zheng, L. Tang, X. D. Xian et al., “Inhibitory effect of triterpenoid saponins from the leaves of ilex kudingcha on aggregated LDL-induced lipid deposition in macrophages,” Planta Medica, vol. 75, no. 13, pp. 1410–1414, 2009.
- C. H. Huang, Y. Y. Chang, C. W. Liu et al., “Fruiting body of niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage,” Journal of Agricultural and Food Chemistry, vol. 58, no. 6, pp. 3859–3866, 2010.
- H. Higashi, K. Yokoyama, Y. Fujii et al., “EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells,” Journal of Biological Chemistry, vol. 280, no. 24, pp. 23130–23137, 2005.
- H. Li and V. Papadopoulos, “Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern,” Endocrinology, vol. 139, no. 12, pp. 4991–4997, 1998.