Table 1: Blood glucose levels following a single oral dose of cytopiloyne in fed db/db mice. Diabetic db/db mice aged 6 to 8 weeks, with free access to food, were grouped and tube-fed with vehicle, glimepiride (GLM) at 2.5 mg/kg/day, and cytopiloyne (CP) at 0.1, 0.5, and 2.5 mg/kg/day. A half-hour after tube feeding was set as time 0. Blood samples were collected from the mice at the indicated time intervals (0, 1, 2, and 4 h). The blood glucose levels were determined using a glucometer. The number of mice ( ) tested is indicated in parentheses in the first column.

Treatment Blood glucose level (mg/dL)
0124 (h)

Vehicle ( )365 ± 9309 ± 4281 ± 9240 ± 11
GLM 2.5 mg/kg ( )378 ± 9237 ± 16*178 ± 20*187 ± 6*
CP 0.1 mg/kg ( )373 ± 6267 ± 12204 ± 17*158 ± 18*
CP 0.5 mg/kg ( )369 ± 27214 ± 15*163 ± 8*132 ± 11*
CP 2.5 mg/kg ( )365 ± 9207 ± 11*147 ± 12*129 ± 11*

as determined by ANOVA.