Table 2: Blood insulin levels following a single oral dose of cytopiloyne in fed db/db mice. Diabetic db/db mice aged 6 to 8 weeks received the same treatment as those in Table 1. Blood samples at the indicated time interval (0, 0.5, 1, 2, and 4 h) were collected from the mice and the insulin levels in each blood sample were determined using ELISA kits. The number of mice ( ) is indicated in parentheses in the first column.

Treatment Blood insulin level ( g/L)
00.5124 (h)

Vehicle ( )13.8 ± 1.911.5 ± 1.910.3 ± 2.48.3 ± 0.78.6 ± 1.9
GLM 2.5 mg/kg ( )13.9 ± 1.219.3 ± 4.226.3 ± 3.3*15.9 ± 1.7*11.8 ± 2.1*
CP 0.1 mg/kg ( )17.2 ± 4.721.0 ± 1.3*15.5 ± 0.6*14.1 ± 0.59.7 ± 1.3
CP 0.5 mg/kg ( )15.7 ± 1.922.6 ± 1.9*16.0 ± 2.4*12.8 ± 0.7*12.2 ± 1.9
CP 2.5 mg/kg ( )12.5 ± 1.225.5 ± 1.2*18.9 ± 3.3*17.6 ± 1.7*8.9 ± 2.1

as determined by ANOVA.