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- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 686018, 15 pages
Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model
1Research Center of Universidade Paulista, Rua Dr. Bacelar 1212, 5th Floor, 04026-002 São Paulo, SP, Brazil
2Laboratory of Veterinary Pathology, Universidade de Santo Amaro, São Paulo, SP, Brazil
3Instituto de Ensino, Pesquisa e Desenvolvimento Royal, São Roque, SP, Brazil
4Laboratory of Immunology, Universidade Federal de São Paulo, São Paulo, SP, Brazil
Received 9 October 2012; Revised 3 December 2012; Accepted 20 December 2012
Academic Editor: Ke Ren
Copyright © 2013 Leoni Villano Bonamin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. van Wijk, J. Clausen, and H. Albrecht, “The rat in basic therapeutic research in homeopathy,” Homeopathy, vol. 98, no. 4, pp. 280–286, 2009.
- A. R. Khuda-Bukhsh, “Mice as a model for homeopathy research,” Homeopathy, vol. 98, no. 4, pp. 267–279, 2009.
- L. V. Bonamin and P. C. Endler, “Animal models for studying homeopathy and high dilutions: conceptual critical review,” Homeopathy, vol. 99, no. 1, pp. 37–50, 2010.
- P. Endler, K. Thieves, C. Reich et al., “Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10−23: a bibliometric study,” Homeopathy, vol. 99, no. 1, pp. 25–36, 2010.
- P. Bellavite, A. Conforti, V. Piasere, and R. Ortolani, “Immunology and homeopathy. 1. Historical background,” Evidence-Based Complementary and Alternative Medicine, vol. 2, no. 4, pp. 441–452, 2005.
- P. Bellavite, A. Conforti, F. Pontarollo, and R. Ortolani, “Immunology and homeopathy. 2. Cells of the immune system and inflammation,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 1, pp. 13–24, 2006.
- P. Bellavite, R. Ortolani, and A. Conforti, “Immunology and homeopathy. 3. Experimental studies on animal models,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 2, pp. 171–186, 2006.
- P. Bellavite, R. Ortolani, F. Pontarollo, V. Piasere, G. Benato, and A. Conforti, “Immunology and homeopathy. 4. Clinical studies—part 2,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 4, pp. 397–409, 2006.
- P. Bellavite, R. Ortolani, F. Pontarollo, G. Pitari, and A. Conforti, “Immunology and homeopathy. 5. The rationale of the ‘Simile’,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 2, pp. 149–163, 2007.
- A. Conforti, P. Bellavite, S. Bertani, F. Chiarotti, F. Menniti-Ippolito, and R. Raschetti, “Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies,” BMC Complementary and Alternative Medicine, vol. 7, article 1, 2007.
- L. V. Bonamin, K. S. Martinho, A. L. Nina, F. Caviglia, and R. G. W. Do Rio, “Very high dilutions of dexamethasone inhibit its pharmacological effects in vivo,” Homeopathy, vol. 90, no. 4, pp. 198–203, 2001.
- J. R. Guedes, S. Carrasco, C. M. Ferreira, et al., “Ultra high dilution of triiodothyronine modifies cellular apoptosis in Rana catesbeiana tadpole tail in vitro,” Homeopathy, vol. 100, no. 4, pp. 220–227, 2011.
- C. Sato, V. G. Listar, and L. V. Bonamin, “Development of broiler chickens after treatment with thymulin 5cH: a zoo technical approach,” Homeopathy, vol. 101, no. 1, pp. 68–73, 2012.
- K. S. Martinho, V. D. B. de Bento, G. U. Benvenga, V. A. Marcondes, and L. V. Bonamin, “Hepatic cell growth models for the study of ultra high dilutions,” in Signal and Images: Contributions and Contradictions About High Dilution Research, L. V. Bonamin, Ed., pp. 83–96, Springer, Dordrecht, The Netherlands, 2008.
- V. Daurat, P. Dorfman, and M. Bastide, “Immunomodulatory activity of low doses of interferon α,β in mice,” Biomedicine and Pharmacotherapy, vol. 42, no. 3, pp. 197–206, 1988.
- M. Bastide, V. Daurat, M. Doucet-Jaboeuf, A. Pelegrin, and P. Dorfman, “Immunomodulator activity of very low doses of thymulin in mice,” International Journal of Immunotherapy, vol. 3, no. 3, pp. 191–200, 1987.
- M. Bastide, M. Doucet-Jaboeuf, and V. Daurat, “Activity and chronopharmacology of very low doses of physiological immune inducers,” Immunology Today, vol. 6, no. 8, pp. 234–235, 1985.
- M. Guennoun, F. Boudard, C. Cabaner, Y. Robbe, J. B. Dubois, and M. Bastide, “Radioprotection and immune system regeneration of irradiated mice by using high dilution treatment,” Chronobiology International, vol. 14, supplement 1, article 60, 1997.
- R. L. Toledo, Associação timulina-isoterápico de ciclofosfamida no tratamento de camundongos portadores de tumor de Erlich, Research Center—UNIP, Universidade Paulista, São Paulo, Brazil, 2005.
- F. R. M. Soto, E. R. Vuaden, C. D. Coelho, N. R. Benites, L. V. Bonamin, and S. S. de Azevedo, “A randomized controlled trial of homeopathic treatment of weaned piglets in a commercial swine herd,” Homeopathy, vol. 97, no. 4, pp. 202–205, 2008.
- J. F. Bach, M. Dardenne, J. M. Pleau, and M. A. Bach, “Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human,” Annals of the New York Academy of Sciences, vol. 249, pp. 186–210, 1975.
- K. Inagaki-Ohara, N. Kobayashi, H. Nishimura et al., “Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil,” Cellular Immunology, vol. 171, no. 1, pp. 30–40, 1996.
- O. A. Brown, Y. E. Sosa, M. Dardenne, J. M. Pléau, and R. G. Goya, “Studies on the gonadotropin-releasing activity of thymulin: changes with age,” Journals of Gerontology Series A, vol. 55, no. 4, pp. B170–B176, 2000.
- M. Dardenne, “Role of thymic peptides as transmitters between the neuroendocrine and immune systems,” Annals of Medicine, vol. 31, supplement 2, pp. 34–39, 1999.
- M. Dardenne, N. Saade, and B. Safieh-Garabedian, “Role of thymulin or its analogue as a new analgesic molecule,” Annals of the New York Academy of Sciences, vol. 1088, pp. 153–163, 2006.
- P. C. Reggiani, G. R. Morel, G. M. Cónsole et al., “The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin,” Annals of the New York Academy of Sciences, vol. 1153, pp. 98–106, 2009.
- L. Santarelli, M. Bracci, and E. Mocchegiani, “Influence of mercury on thymulin production: metallothioneins role,” Giornale Italiano di Medicina del Lavoro ed Ergonomia, vol. 27, no. 3, pp. 335–338, 2005.
- B. Kallen, M. Dohlsten, and H. Klementsson, “Effect of cyclophosphamide pretreatment on autoimmune encephalomyelitis in rats,” Acta Neurologica Scandinavica, vol. 73, no. 4, pp. 338–344, 1986.
- N. Hirai, H. Furuyama, A. Awaya, and M. Onuma, “Effect of administration of serum thymic factor (FTS) in calves and rabbits infected with bovine immunodeficiency-like virus.,” The Journal of Veterinary Medical Science, vol. 57, no. 2, pp. 307–310, 1995.
- N. Saitoh, A. Awaya, A. Sakudo et al., “Serum thymic factor prevents LPS-induced pancreatic cell damage in mice via up-regulation of Bcl-2 expression in pancreas,” Microbiology and Immunology, vol. 48, no. 9, pp. 629–638, 2004.
- J. Yasuda, W. Nishioka, A. Sakudo et al., “Suppressor mechanism of serum thymic factor on tumor necrosis factor-α-induced apoptosis in the mouse pancreatic β-cell line,” Biochemical and Biophysical Research Communications, vol. 311, no. 2, pp. 501–505, 2003.
- H. Aono, M. Morishita, M. Sasano et al., “Amelioration of type II collagen induced arthritis in rats by treatment with thymulin,” Journal of Rheumatology, vol. 24, no. 8, pp. 1564–1569, 1997.
- A. F. Vigna, S. R. Almeida, P. Xander, E. Freymüller, M. Mariano, and J. D. Lopes, “Granuloma formation in vitro requires B-1 cells and is modulated by Paracoccidioides brasiliensis gp43 antigen,” Microbes and Infection, vol. 8, no. 3, pp. 589–597, 2006.
- A. F. Popi, F. L. T. Motta, R. A. Mortara, S. Schenkman, J. D. Lopes, and M. Mariano, “Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro,” Immunology, vol. 126, no. 1, pp. 114–122, 2009.
- A. F. Popi, D. S. Zamboni, R. A. Mortara, and M. Mariano, “Microbicidal property of B1 cell derived mononuclear phagocyte,” Immunobiology, vol. 214, no. 8, pp. 664–673, 2009.
- H. C. Oliveira, A. F. Popi, A. L. L. Bachi, S. Nonogaki, J. D. Lopes, and M. Mariano, “B-1 cells modulate the kinetics of wound-healing process in mice,” Immunobiology, vol. 215, no. 3, pp. 215–222, 2010.
- M. F. Nogueira-Martins and M. Mariano, “B-1 cell participation in T-cell-mediated alloimmune response,” Immunobiology, vol. 215, no. 4, pp. 264–274, 2010.
- R. T. Russo and M. Mariano, “B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection,” Immunobiology, vol. 215, no. 12, pp. 1005–1014, 2010.
- H. Ohdan, K. G. Swenson, H. S. Kruger Gray et al., “Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Galα1,3Gal epitopes α1,3-galactosyltransferase-deficient mice,” Journal of Immunology, vol. 165, no. 10, pp. 5518–5529, 2000.
- T. Kawahara, H. Ohdan, G. Zhao, Y. G. Yang, and M. Sykes, “Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells,” Journal of Immunology, vol. 171, no. 10, pp. 5406–5414, 2003.
- L. A. Herzenberg, A. M. Stall, and P. A. Lalor, “The LY-1 B cell lineage,” Immunological Reviews, vol. 93, pp. 81–102, 1986.
- N. Baumgarth, “The double life of a B-1 cell: self-reactivity selects for protective effector functions,” Nature Reviews Immunology, vol. 11, no. 1, pp. 34–46, 2011.
- A. O'Garra, R. Chang, N. Go, R. Hastings, G. Haughton, and M. Howard, “Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10,” European Journal of Immunology, vol. 22, no. 3, pp. 711–717, 1992.
- B. Roy, S. Shukla, M. Łyszkiewicz et al., “Somatic hypermutation in peritoneal B1b cells,” Molecular Immunology, vol. 46, no. 8-9, pp. 1613–1619, 2009.
- S. R. Almeida, L. S. Aroeira, E. Frymuller et al., “Mouse B-1 cell-derived mononuclear phagocyte, a novel cellular component of acute non-specific inflammatory exudate,” International Immunology, vol. 13, no. 9, pp. 1193–1201, 2001.
- A. F. Popi, L. Osugui, K. R. Perez, I. M. Longo-Maugéri, and M. Mariano, “Could a B-1 cell derived phagocyte, “be one” of the peritoneal macrophages during LPS-driven inflammation?” PLoS ONE, vol. 7, no. 3, Article ID e34570, 2012.
- K. M. Haas, J. C. Poe, D. A. Steeber, and T. F. Tedder, “B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae,” Immunity, vol. 23, no. 1, pp. 7–18, 2005.
- A. F. Popi, J. D. Lopes, and M. Mariano, “Interleukin-10 secreted by B-1 cells modulates the phagocytic activity of murine macrophages in vitro,” Immunology, vol. 113, no. 3, pp. 348–354, 2004.
- S. Garaud, C. le Dantec, A. R. de Mendoza, R. A. Mageed, P. Youinou, and Y. Renaudineau, “IL-10 production by B Cells expressing CD5 with the alternative exon 1B,” Annals of the New York Academy of Sciences, vol. 1173, pp. 280–285, 2009.
- M. A. Borrello and R. P. Phipps, “Fibroblast-secreted macrophage colony-stimulating factor is responsible for generation of biphenotypic B/macrophage cells from a subset of mouse B lymphocytes,” Journal of Immunology, vol. 163, no. 7, pp. 3605–3611, 1999.
- M. A. Borrello and R. P. Phipps, “The B/macrophage cell: an elusive link between CD5+ B lymphocytes and macrophages,” Immunology Today, vol. 17, no. 10, pp. 471–475, 1996.
- M. A. Borrello and R. P. Phipps, “Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics,” Journal of Immunology, vol. 155, no. 9, pp. 4155–4161, 1995.
- A. Itakura, M. Szczepanik, R. A. Campos et al., “An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity,” Journal of Immunology, vol. 175, no. 11, pp. 7170–7178, 2005.
- H. Moon, J. G. Lee, S. H. Shin, and T. J. Kim, “LPS-induced migration of peritoneal B-1 cells is associated with upregulation of CXCR4 and increased migratory sensitivity to CXCL12,” Journal of Korean Medical Science, vol. 27, no. 1, pp. 27–35, 2012.
- J. S. Mussalem, C. C. Squaiella-Baptistão, D. Teixeira, et al., “Adjuvant effect of killed Propionibacterium acnes on mouse peritoneal B-1 lymphocytes and their early phagocyte differentiation,” PLoS ONE, vol. 7, no. 3, Article ID e33955, 2012.
- J. W. Moore, L. Beattie, J. E. Dalton, et al., “B cell: T cell interactions occur within hepatic granulomas during experimental visceral leishmaniasis,” PLoS ONE, vol. 7, no. 3, Article ID e34143, 2012.
- S. A. Ha, M. Tsuji, K. Suzuki et al., “Regulation of B1 cell migration by signals through toll-like receptors,” Journal of Experimental Medicine, vol. 203, no. 11, pp. 2541–2550, 2006.
- F. L. Oliveira, R. Chammas, L. Ricon et al., “Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells,” Glycobiology, vol. 19, no. 11, pp. 1248–1258, 2009.
- M. Doucet-Jaboeuf, J. Guillemain, and M. Piechaczyk, “Limit-dose evaluation of serum thymic factor activity,” Comptes Rendus des Seances de l'Academie des Sciences—Series III, vol. 295, no. 4, pp. 283–286, 1982.
- H. Kobayashi, H. Abe, T. Ueyama, A. Awaya, and M. Shikita, “Radioprotective effects of serum thymic factor in mice,” Radiation Research, vol. 129, no. 3, pp. 351–356, 1992.
- H. Kobayashi, H. Abe, H. Inano, and M. Shikita, “Serum thymic factor as a radioprotective agent promoting survival after X-irradiation,” Experientia, vol. 46, no. 5, pp. 484–486, 1990.
- P. S. Chikramane, A. K. Suresh, J. R. Bellare, and S. G. Kane, “Extreme homeopathic dilutions retain starting materials: a nanoparticulate perspective,” Homeopathy, vol. 99, no. 4, pp. 231–242, 2010.
- I. R. Bell and M. Koithan, “A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system,” BMC Complementary and Alternative Medicine, vol. 12, no. 1, article 191, 2012.
- B. J. Youbicier-Simo, F. Boudard, M. Mékaouche, J. D. Baylé, and M. Bastide, “A role for bursa fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken,” Journal of Pineal Research, vol. 21, no. 1, pp. 35–43, 1996.
- L. V. Bonamin, C. Landi de Moraes, F. Sanches, et al., “Rats born to mothers treated with dexamethasone 15 cH present changes in modulation of inflammatory process,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 710923, 10 pages, 2012.
- C. M. V. Pedalino, F. F. Perazzo, J. C. T. Carvalho, K. S. Martinho, C. de O Massoco, and L. V. Bonamin, “Effect of Atropa belladonna and Echinacea angustifolia in homeopathic dilution on experimental peritonitis,” Homeopathy, vol. 93, no. 4, pp. 193–198, 2004.
- A. P. Kawakami, C. Sato, T. N. Cardoso, and L. V. Bonamin, “Inflammatory process modulation by homeopathic arnica montana 6CH: the role of individual variation,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 917541, 12 pages, 2011.