Ameliorative Effects of Acanthopanax trifoliatus on Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice: An Animal Model of Depression and Cognitive Deficits
Figure 2
Schematic drawing of experimental schedule. Protocol 1 (a): after one week of acclimatization, the ddY mice were randomly divided into 4 groups of 10 mice. All mice (except mice in the sham group) were subjected to OBX surgery. Three days after the surgery, the drug administration was started. Modified Y-maze and object recognition tests were performed 1 and 3 weeks after starting drug administration, respectively. Quantitative real-time polymerase chain reaction and neurochemical studies were carried out after decapitation of all mice. Protocol 2 (b): after one week of acclimatization, the ddY mice were randomly divided into 4 groups of 6 mice. All mice (except mice in the sham group) were subjected to OBX surgery. Three days after the surgery, the drug administration was started. Tail suspension test was performed 7 days after starting drug administration.
