Research Article

Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells

Figure 1

Protocols for sBr treatment in murine models of allergic airway disease. (a) Mice ( –10 per group) were sensitized to OVA-alum (i.p.) weekly, for 3 consecutive weeks. sBr (6 mg/kg in 0.5 ml PBS) or PBS was delivered i.p. twice daily. On day 0, mice were challenged with OVA aerosol for seven consecutive days and sacrificed (S) 24 hours later. (b) Sensitization and i.p. sBr treatment were the same as in (a). Animals were sacrificed 24 hrs after each week or treatment; S1 (week 1), S2 (week 2), and S3 (week 3). In selected experiments groups of mice were treated with E64-inhibited-sBr.
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(a)
702196.fig.001b
(b)