Research Article

Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells

Figure 3

sBr treatment throughout sensitization reduces production of antigen-specific IgE. Peripheral blood of mice (PBS, sBr, or E64-inhibited-sBr) was collected after each weekly sensitization and serum was processed for concentration of OVA-specific IgE. In PBS-treated controls, a significant increase in the concentration of OVA-specific IgE was noted after i.p.’s 2 and 3 when compared to i.p. 1. In sBr-treated groups, the production OVA-specific IgE was delayed and attenuated relative to PBS groups. IgE production was restored in the E64 treatment group. PBS: phosphate buffered saline, E64: E64-inhibited-sBr ( , between i.p.’s; between PBS treated groups; per group).
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