Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-<svg style="vertical-align:-0.216pt;width:11.4875px;" id="M1" height="10.4375" version="1.1" viewBox="0 0 11.4875 10.4375" width="11.4875" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D705" d="M484 406q0 -21 -22 -38q-10 -7 -18 -1q-15 11 -30 11q-30 0 -77.5 -37t-74.5 -67l79 -168q11 -23 19.5 -34.5t13 -14t10.5 -2.5q9 0 30 17.5t40 42.5l17 -23q-31 -45 -57.5 -69.5t-40.5 -29.5t-31 -5q-18 0 -32 13.5t-35 55.5q-34 71 -69 160q-36 -32 -59 -56
q-12 -27 -36 -158q-44 -7 -77 -15l-5 7l82 349q6 25 -2 25q-16 0 -72 -41l-14 22q44 41 89 69.5t66 28.5q19 0 19 -32q0 -16 -6 -43l-35 -160l146 143q94 92 136 92q20 0 33 -12t13 -30z" /></g></svg>B Pathway in Diabetic Rats

<table>Levels of renal advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) expression in diabetic rats treated with Xiexin decoction. NC: normal control; DM: diabetic model control; XXDL: XXD extract 1.25 g/kg; XXDH: XXD extract 2.5 g/kg; losartan 10 mg/kg and metformin 100 mg/kg. NC and DM were treated with normal saline. All the rats were administered via intragastric gavage once time each day for 12 weeks. Data are presented as means ± S.D, <svg height="13.95" id="M136" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> as compared with DM.</table>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-<svg style="vertical-align:-0.216pt;width:11.4875px;" id="M1" height="10.4375" version="1.1" viewBox="0 0 11.4875 10.4375" width="11.4875" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D705" d="M484 406q0 -21 -22 -38q-10 -7 -18 -1q-15 11 -30 11q-30 0 -77.5 -37t-74.5 -67l79 -168q11 -23 19.5 -34.5t13 -14t10.5 -2.5q9 0 30 17.5t40 42.5l17 -23q-31 -45 -57.5 -69.5t-40.5 -29.5t-31 -5q-18 0 -32 13.5t-35 55.5q-34 71 -69 160q-36 -32 -59 -56
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Figure 3 | Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-B Pathway in Diabetic Rats 