Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-B Pathway in Diabetic Rats
Figure 6
Reliability evaluation for the pharmacokinetics/pharmacodynamics analysis using partial least squares models and regression coefficients between pharmacokinetic parameter of ingredients with effective indicators in diabetic nephropathy rats treated with XXD for 12 weeks. : square of correlation coefficients; : the cross-validated correlation coefficients, : significance using ANOVA. Rhe: Rhein; Emo: emodin; BG: baicalin; WG: wogonoside; W: wogonin; Ber: berberine; Jat: jatrorrhizine; Pal: palmatine. : the maximum plasma concentration; AUC: the area under the curve of plasma concentration of ingredient; UAE: Urinary albumin excretion; M/G: ratio of mesangial matrix area to glomerular area; GAUC: area under the blood glucose response curve; AGEs: advanced glycation end-products; ICAM-1: intercellular adhesion molecule-1; MCP-1: monocyte chemotactic protein-1; IL-6: interleukin-6; TNF-α: tumor necrosis factor-α; NF-κBp65: nuclear factor-κBp65; TGF-β1: transforming growth factor β1. ICAM-1, MCP-1, TGF-1, and NF-κB panels show mRNA expression.
