Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-𝜅B Pathway in Diabetic Rats

Table 3

Pharmacokinetic parameters of effective ingredients after intragastric gavage of Xiexin decoction for 12 weeks in diabetic rats.

Constituents	1.25 g/kg		2.5 g/kg
	𝐶max (μg/mL)	AUC0--24h (μg·h/mL)	𝐶max (μg/mL)	AUC0--24h (μg·h/mL)
Rhein	0.961±0.430	1.102±0.216	1.753±0.514	2.789±0.937
Emodin	0.013±0.007	0.061±0.008	0.022±0.009	0.119±0.025
Baicalin	1.564±0.570	4.696±1.734	4.309±1.709	16.067±9.597
Wogonoside	1.137±0.321	3.458±0.894	2.240±0.475	8.884±2.992
Wogonin	0.047±0.038	0.154±0.071	0.149±0.086	0.423±0.307
Berberine	0.051±0.020	0.757±0.389	0.118±0.078	1.727±1.037
Palmatine	0.017±0.013	0.113±0.069	0.029±0.018	0.312±0.197
Jatrorrhizine	0.014±0.009	0.172±0.057	0.021±0.013	0.201±0.152

Data are expressed as mean ± SD, 𝑛=8 in each group.