Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
Table 3
List of identified differential metabolites between the sham and model group on day 3.
tR (min)
Metabolites
VIPa
Fold changec (model/sham)
Metabolic pathways
6.34
Glycine
1.6
0.0029
Amino acid metabolism
7.14
Urea
1.4
0.0221
1.4
Nucleic acid metabolism
7.64
L-alanine
1.4
0.0134
1.3
Amino acid metabolism
8.72
L-isoleucine
2.5
0.0000
Amino acid metabolism
8.9
Cadaverine
1.6
0.0058
2.1
Not known
9.01
Succinic acid
1.2
0.0532
Energy metabolism
9.52
2-Butenedioic acid
1.9
0.0003
Energy metabolism
9.96
L-threonine
2.0
0.0002
Amino acid metabolism
11.06
Aminomalonic acid
1.3
0.0236
Amino acid metabolism
11.69
L-aspartic acid
2.3
0.0000
1.1
Amino acid metabolism
11.72
L-proline
2.0
0.0002
Amino acid metabolism
12.14
Creatinine
1.7
0.0010
1.2
Amino acid metabolism
13.04
L-phenylalanine
1.3
0.0192
1.4
Energy metabolism
16.18
Citric acid
1.3
0.0407
Energy metabolism
16.86
D-xylose
1.2
0.0328
1.2
Nucleic acid metabolism
16.89
D-glucose
1.7
0.0017
1.7
Energy metabolism
17.19
Lactic acid
1.8
0.0010
1.6
Energy metabolism
17.58
L-tyrosine
1.7
0.0016
1.2
Amino acid metabolism
19.84
Propanoic acid
1.3
0.0138
Energy metabolism
21.95
L-tryptophan
1.7
0.0012
1.1
Amino acid metabolism
aVariable importance in the projection (VIP) was obtained from OPLS-DA with a threshold of 1.0. b values were calculated from Student’s -test. cFold change was calculated from the arithmetic mean values of each group. Fold change with a positive value indicates a relatively higher concentration present in model group while a negative value means a relatively lower concentration as compared to the sham group.
