Evidence-Based Complementary and Alternative Medicine

Research Article

Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats

Table 4

Summary of intensity values of potential biomarkers in each group on day 3.


Biomarkers	Peak intensity (mean ± sd, )
Biomarkers	Control	Con. + CDDP	Sham	Model	Mod. + CDDP

Glycine	5.86 ± 0.6^b,c	5.51 ± 0.96^b	4.85 ± 0.94^a	4.41 ± 1.65^a	5.94 ± 1.8^b,c
Urea	190.9 ± 112.08^b	201.44 ± 108.76^b	201.59 ± 55.12^b	282.23 ± 72.75^a,c	211.97 ± 48.32^b
L-alanine	444.97 ± 64.71^b	432.48 ± 74.21^b	450.96 ± 56.85^b	586.25 ± 64.89^a,c	443.53 ± 98.11^b
L-isoleucine	260.88 ± 34.02^b,c	254.42 ± 39.69^b	211.84 ± 34.61^a,b	192.58 ± 33.25^ac	205.51 ± 54.06^a
Cadaverine	22.75 ± 11.3^b	23.12 ± 4.15^b	21.68 ± 11.31^b	45.53 ± 11.1^a,c	36.9 ± 14.92^b
Succinic acid	3.12 ± 2.16^b	3.13 ± 0.94^b	3.13 ± 1.63^b	2.40 ± 1.01^a	3.01 ± 2.07^b
2-Butenedioic acid	4.74 ± 1.61^b	4.61 ± 3.24^b	4.23 ± 3.98^b	1.24 ± 3.92^a,c	3.37 ± 3.98^a,b
L-threonine	209.33 ± 25.38^b,c	208.3 ± 27.54^b	181.25 ± 22.81^a,b	164.77 ± 35.78^a,c	189.33 ± 44.05^b
Aminomalonic acid	46.73 ± 29.21^b	46.21 ± 18.02^b	43.69 ± 44.56^b	36.41 ± 28.42^a,c	39.85 ± 25.14^a
L-aspartic acid	100.32 ± 11.51^b	97.98 ± 13.89^b	102.57 ± 7^b	112.83 ± 13.89^a,c	104.12 ± 21.12^b
L-proline	280.57 ± 22.74^b,c	289.33 ± 56.22^b	218.72 ± 31.35^a,b	95.1 ± 15.54^a,c	248.84 ± 64.37^b
Creatinine	6.39 ± 1.59^b,c	6.27 ± 3.44^b	7.25 ± 3.23^a,b	8.7 ± 3.73^ac	7.71 ± 3.24^a,b
L-phenylalanine	110.09 ± 10.46^b,c	106.57 ± 14.11^b	126.76 ± 8.24^a,b	177.46 ± 12.68^a,c	148.95 ± 24.79^a,b
Citric acid	6.95 ± 5.52^b	6.83 ± 4.4^b	6.33 ± 4.45^b	5.75 ± 2.64^a,c	6.06 ± 3.71^a,b
D-xylose	7.01 ± 1.96^b,c	7.08 ± 1.06^b	8.13 ± 1.07^a,b	9.76 ± 1.77^a,c	8.07 ± 1.15^b
D-glucose	2912.13 ± 190.45^b	2993.74 ± 210.95^b	3239.06 ± 255.96^b	5506.4 ± 255.01^a,c	3012.34 ± 209.33^b
Lactic acid	210.17 ± 15.22^b	211.91 ± 22.87^b	238.35 ± 16.13^b	381.36 ± 24.33^a,c	258.68 ± 16.45^b
L-tyrosine	44.57 ± 5.36^b,c	43.47 ± 7.74^b	56.62 ± 5.38^a,b	67.94 ± 9.93^a,c	62.72 ± 9.05^a
Propanoic acid	21.98 ± 6.65^b,c	22.5 ± 10.64^b	11.98 ± 6.28^a	10.89 ± 9.27^a	14.96 ± 10.47^a,b
L-tryptophan	421.7 ± 67.69^b	417.94 ± 69.49^b	434.8 ± 82.32^b	478.28 ± 118.65^a,c	451.78 ± 101.75^a,b

Compared with the control group, ^a; compared with the model group, ^b; compared with the sham group, ^c.