Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs

Figure 4

Effect of 194-A on VEGF-C or FGF-2-induced invasive effects in mammary carcinoma cells. Relative invasion of 4T1 and MDA-MB231 grown in low-serum (1% FBS) media supplemented with 100 ng/mL of VEGF-C (a) or 20 ng/mL FGF-2 (b) as indicated. Invasive ability was reduced in a dose-dependent manner in response to 194-A treatment. Mean value of three replicates, normalized to the untreated controls; bars, SE. *𝑃<0.05; **𝑃<0.01 as compared to the VEGF-C or FGF-2 treatment group.

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