Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats

Figure 4

RCE inhibited plasma ET-1, BALF VEGF, and HIF-1α expressions in hypoxia-treated animals. Hypoxia increased and RCE attenuated (a) plasma ET-1 level (𝑛=6), (b) BALF VEGF level (𝑛=6), and (c) HIF-1α protein expression level (𝑛=3). (d) Quantitative analysis of the relative level of HIF-1α from (c). Results represent mean ± SEM. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001 versus control; ^#𝑃<0.05; ^##𝑃<0.01; ^###𝑃<0.001  versus hypoxia (H).

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