Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers

<table>Induction of CYP3A4 mRNA by tanshinone I (TanI), cryptotanshinone (Cry), tanshinone IIA (Tan IIA), and dihydrotanshinone I (DHTanI). Human hepatocytes were exposed to tanshinone I (2 <i>μ</i>M), cryptotanshinone (2 <i>μ</i>M), tanshinone IIA (2 <i>μ</i>M), dihydrotanshinone I (2 <i>μ</i>M), or 25 <i>μ</i>M rifampin (PC) for 3 days. CYP3A4 mRNA levels were measured with reverse transcription real-time PCR. These data were obtained from two independent experiments, and each experiment was performed in triplicate. Each column with bar represents the mean and S.D. The mean is expressed as fold induction over vehicle control (NC).</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers 