Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers

Table 2

Pharmacokinetic parameters of tanshinons in 12 healthy volunteers after single- and multiple-dose administration of the ethanol extract of danshen.

PK parameter	Tanshinone I	Cryptotanshinone	Tanshinone IIA	Dihydrotanshinone I
𝐶max (ng/mL)	11.52±9.90	3.44±1.32	4.00±2.79	0.85±0.59
𝐶trough (ng/mL)	3.09±1.09	0.76±0.23	1.36±0.52	0.20±0.15
𝐶ssmax (ng/mL)	18.10±16.44	3.33±1.85	3.98±1.97	1.00±0.56

Data are mean value ± SD.
𝐶_max: peak plasma concentration after single-dose administration of the danshen extract; 𝐶_{𝑡𝑟𝑜𝑢𝑔ℎ}: plasma trough concentration at the end of a dosing interval after multiple-dose administration of the danshen extract; 𝐶_ssmax: peak plasma concentration at the end of a dosing interval after multiple-dose administration of the danshen extract.