Research Article
Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer
Table 3
Relationship between TGFA gene polymorphisms and the ZHENG of GC.
| | SNPs | Genotype | Type of ZHENG (%) | | | | SSD | YDSH | DQY | DQB | DLS | DHT | SPM | OBS | Other |
| | rs3771527 | TT | 39 (67.2) | 37 (68.5) | 15 (71.4) | 26 (56.5) | 32 (80.0) | 37 (69.8) | 25 (64.1) | 22 (64.7) | 16 (76.2) | 21.067 | 0.176 | | TA | 16 (27.6) | 17 (31.5) | 4 (19.0) | 20 (43.5) | 8 (20.0) | 13 (24.5) | 13 (33.3) | 11 (32.4) | 3 (14.3) | — | — | | AA | 3 (5.2) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 3 (5.7) | 1 (2.6) | 1 (2.9) | 2 (9.5) | — | — | | TA/AA | 19 (32.8) | 17 (31.5) | 6 (28.6) | 20 (43.5) | 8 (20.0) | 16 (30.2) | 14 (35.9) | 12 (35.3) | 5 (23.8) | 6.740 | 0.565 | | T allele | 94 (81.0) | 91 (84.3) | 34 (81.0) | 72 (78.3) | 72 (90.0) | 87 (82.1) | 63 (80.8) | 55 (80.9) | 35 (83.3) | 5.019 | 0.756 | | A allele | 22 (19.0) | 17 (15.7) | 8 (19.0) | 20 (21.7) | 8 (10.0) | 19 (17.9) | 15 (19.2) | 13 (19.1) | 7 (16.7) | — | — |
| | rs538118 | AA | 27 (45.8) | 24 (41.4) | 13 (56.5) | 27 (56.2) | 24 (58.5) | 27 (50.9) | 21 (52.5) | 17 (48.6) | 9 (40.9) | 11.900 | 0.751 | | GA | 26 (44.1) | 28 (48.3) | 6 (26.1) | 15 (31.2) | 15 (36.6) | 23 (43.4) | 16 (40.0) | 15 (42.9) | 12 (54.5) | — | — | | GG | 6 (10.2) | 6 (10.3) | 4 (17.4) | 6 (12.5) | 2 (4.9) | 3 (5.7) | 3 (7.5) | 3 (8.6) | 1 (4.5) | — | — | | GA/GG | 32 (54.2) | 34 (58.6) | 10 (43.5) | 21 (43.8) | 17 (41.5) | 26 (49.1) | 19 (47.5) | 18 (51.4) | 13 (59.1) | 5.356 | 0.719 | | A allele | 80 (67.8) | 76 (65.5) | 32 (69.6) | 69 (71.9) | 63 (76.8) | 77 (72.6) | 58 (72.5) | 49 (70.0) | 30 (68.2) | 3.99 | 0.858 | | G allele | 38 (32.2) | 40 (34.5) | 14 (30.4) | 27 (28.1) | 19 (23.2) | 29 (27.4) | 22 (27.5) | 21 (30.0) | 14 (31.8) | — | — |
| | rs473698 | CC | 28 (45.9) | 25 (43.1) | 13 (56.5) | 27 (56.2) | 24 (55.8) | 29 (53.7) | 20 (50.0) | 18 (52.9) | 9 (40.9) | 6.733 | 0.978 | | GC | 27 (44.3) | 28 (48.3) | 8 (34.8) | 16 (33.3) | 16 (37.2) | 23 (42.6) | 17 (42.5) | 14 (41.2) | 11 (50.0) | — | — | | GG | 6 (9.8) | 5 (8.6) | 2 (8.7) | 5 (10.4) | 3 (7.0) | 2 (3.7) | 3 (7.5) | 2 (5.9) | 2 (9.1) | — | — | | GC/GG | 33 (54.1) | 33 (56.9) | 10 (43.5) | 21 (43.8) | 19 (44.2) | 25 (46.3) | 20 (50.0) | 16 (47.1) | 13 (59.1) | 4.354 | 0.824 | | C allele | 83 (68.0) | 78 (67.2) | 34 (73.9) | 70 (72.9) | 64 (74.4) | 81 (75.0) | 57 (71.3) | 50 (73.5) | 29 (65.9) | 3.766 | 0.878 | | G allele | 39 (32.0) | 38 (32.8) | 12 (26.1) | 26 (27.1) | 22 (25.6) | 27 (25.0) | 23 (28.8) | 18 (26.5) | 15 (34.1) | — | — |
| | rs3732253 | CC | 33 (54.1) | 25 (43.1) | 10 (43.5) | 25 (52.1) | 18 (41.9) | 19 (35.2) | 16 (40.0) | 20 (57.1) | 11 (50.0) | 15.486 | 0.489 | | TC | 23 (37.7) | 27 (46.6) | 8 (34.8) | 19 (39.6) | 22 (51.2) | 31 (57.4) | 20 (50.0) | 14 (40.0) | 8 (36.4) | — | — | | TT | 5 (8.2) | 6 (10.3) | 5 (21.7) | 4 (8.3) | 3 (7.0) | 4 (7.4) | 4 (10.0) | 1 (2.9) | 3 (13.6) | — | — | | TC/TT | 28 (45.9) | 33 (56.9) | 13 (56.5) | 23 (47.9) | 25 (58.1) | 35 (64.8) | 24 (60.0) | 15 (42.9) | 11 (50.0) | 7.887 | 0.445 | | C allele | 89 (73.0) | 77 (66.4) | 28 (60.9) | 69 (71.9) | 58 (67.4) | 69 (63.9) | 52 (65.0) | 54 (77.1) | 30 (68.2) | 7.097 | 0.526 | | T allele | 33 (27.0) | 39 (33.6) | 18 (39.1) | 27 (28.1) | 28 (32.6) | 39 (36.1) | 28 (35.0) | 16 (22.9) | 14 (31.8) | — | — |
| | rs11466306 | GG | 33 (54.1) | 22 (37.9) | 7 (31.8) | 25 (52.1) | 17 (40.5) | 20 (37.0) | 18 (45.0) | 20 (57.1) | 11 (50.0) | 15.477 | 0.490 | | GA | 23 (37.7) | 30 (51.7) | 10 (45.5) | 18 (37.5) | 22 (52.4) | 30 (55.6) | 18 (45.0) | 13 (37.1) | 8 (36.4) | — | — | | AA | 5 (8.2) | 6 (10.3) | 5 (22.7) | 5 (10.4) | 3 (7.1) | 4 (7.4) | 4 (10.0) | 2 (5.7) | 3 (13.6) | — | — | | GA/AA | 28 (45.9) | 36 (62.1) | 15 (68.2) | 23 (47.9) | 25 (59.5) | 34 (63.0) | 22 (55.0) | 15 (42.9) | 11 (50.0) | 9.743 | 0.284 | | G allele | 89 (73.0) | 74 (63.8) | 24 (54.5) | 68 (70.8) | 56 (66.7) | 70 (64.8) | 54 (67.5) | 53 (75.7) | 30 (68.2) | 8.786 | 0.361 | | A allele | 33 (27.0) | 42 (36.2) | 20 (45.5) | 28 (29.2) | 28 (33.3) | 38 (35.2) | 26 (32.5) | 17 (24.3) | 14 (31.8) | — | — |
| | rs11466285 | TT | 48 (80.0) | 48 (84.2) | 20 (90.9) | 39 (81.2) | 27 (67.5) | 49 (92.5) | 28 (70.0) | 22 (62.9) | 18 (81.8) | 31.012 | 0.013 | | TC | 12 (20.0) | 9 (15.8) | 2 (9.1) | 9 (18.8) | 13 (32.5) | 4 (7.5) | 12 (30.0) | 12 (34.3) | 3 (13.6) | — | — | | CC | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.9) | 1 (4.5) | — | — | | TC/CC | 12 (20.0) | 9 (15.8) | 2 (9.1) | 9 (18.8) | 13 (32.5) | 4 (7.5) | 12 (30.0) | 13 (37.1) | 4 (18.2) | 19.716 | 0.011 | | T allele | 108 (90.0) | 105 (92.1) | 42 (95.5) | 87 (90.6) | 67 (83.8) | 102 (96.2) | 68 (85.0) | 56 (80.0) | 39 (88.6) | 18.86 | 0.016 | | C allele | 12 (10.0) | 9 (7.9) | 2 (4.5) | 9 (9.4) | 13 (16.3) | 4 (3.8) | 12 (15.0) | 14 (20.0) | 5 (11.4) | — | — |
| | rs503314 | GG | 24 (42.9) | 20 (36.4) | 9 (47.4) | 22 (48.9) | 21 (53.8) | 26 (52.0) | 19 (48.7) | 16 (47.1) | 8 (38.1) | 6.720 | 0.978 | | GC | 25 (44.6) | 28 (50.9) | 7 (36.8) | 17 (37.8) | 15 (38.5) | 20 (40.0) | 17 (43.6) | 15 (44.1) | 10 (47.6) | — | — | | CC | 7 (12.5) | 7 (12.7) | 3 (15.8) | 6 (13.3) | 3 (7.7) | 4 (8.0) | 3 (7.7) | 3 (8.8) | 3 (14.3) | — | — | | GC/CC | 32 (57.1) | 35 (63.6) | 10 (52.6) | 23 (51.1) | 18 (46.2) | 24 (48.0) | 20 (51.3) | 18 (52.9) | 13 (61.9) | 4.793 | 0.780 | | G allele | 73 (65.2) | 68 (61.8) | 25 (65.8) | 61 (67.8) | 57 (73.1) | 72 (72.0) | 55 (70.5) | 47 (69.1) | 26 (61.9) | 4.985 | 0.759 | | C allele | 39 (34.8) | 42 (38.2) | 13 (34.2) | 29 (32.2) | 21 (26.9) | 28 (28.0) | 23 (29.5) | 21 (30.9) | 16 (38.1) | — | — |
| | rs2166975 | GG | 31 (54.4) | 24 (42.1) | 9 (42.9) | 23 (51.1) | 17 (41.5) | 20 (38.5) | 16 (39.0) | 21 (63.6) | 10 (45.5) | 13.479 | 0.637 | | GA | 21 (36.8) | 26 (45.6) | 7 (33.3) | 17 (37.8) | 20 (48.8) | 26 (50.0) | 19 (46.3) | 9 (27.3) | 8 (36.4) | — | — | | AA | 5 (8.8) | 7 (12.3) | 5 (23.8) | 5 (11.1) | 4 (9.8) | 6 (11.5) | 6 (14.6) | 3 (9.1) | 4 (18.2) | — | — | | GA/AA | 26 (45.6) | 33 (57.9) | 12 (57.1) | 22 (48.9) | 24 (58.5) | 32 (61.5) | 25 (61.0) | 12 (36.4) | 12 (54.5) | 8.959 | 0.346 | | G allele | 83 (72.8) | 74 (64.9) | 25 (59.5) | 63 (70.0) | 54 (65.9) | 66 (63.5) | 51 (62.2) | 51 (77.3) | 28 (63.6) | 8.268 | 0.408 | | A allele | 31 (27.2) | 40 (35.1) | 17 (40.5) | 27 (30.0) | 28 (34.1) | 38 (36.5) | 31 (37.8) | 15 (22.7) | 16 (36.4) | — | — |
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