Table 2: Topological properties of the 2-HN for SHU formula and its three subnetworks.

PropertyCSNPSNGSN2-HN

NodeCompounds171500171
Proteins0 238238238
Edge CCIs48100481
CPIs0110101101
PPIs00718718
Connected components341571
Isolated nodes 170550
Clustering coefficient0.6620.00.1980.414
Network density0.0330.0270.0250.028
Network heterogeneity0.6642.5311.2871.588

CCI is short for compound-compound interaction, CPI is compound-protein interaction, and PPI is protein-protein interaction. CSN represents the chemical subnetwork of the 2-HN for SHU formula, PSN the pharmacological subnetwork, and GSN the genomic subnetwork.
All the topological properties were calculated using Cytoscape 2.8 [32].