A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula

Table 3

“Hub” herbal compounds identified from the pharmacological subnetwork of the 2-HN for SHU formula.

Name	CAS RN	PubChem CID	PI	Action	Reference
Quercetin	117-39-5	5280343	222	(i) Quercetin and rutin exhibit prooxidant effect in healthy and antioxidant activity in influenza—infected animals.	[39]
				(ii) Quercetin and oseltamivir exhibited antivirus effect on the Toll-like receptor 7 (TLR7) signaling pathway when dendritic cells and macrophages were infected with H1N1.	[40]
Resveratrol	501-36-0	445154	218	Resveratrol inhibited the replication of influenza virus in MDCK cells.	[43]
Kaempferol	520-18-3	5280863	67	Kaempferol inhibited influenza A nucleoprotein production in human lung epithelial (A549) cells infected with the H5N1 virus strain A/Thailand/Kan-1/04 in non-toxic concentrations.	[44]
Eugenol	97-53-0	3314	61	Eugenol could inhibit autophagy and influenza A virus replication, inhibit the activation of ERK, p38MAPK and IKK/NF-𝜅B signal pathways.	[45]

∗PI is Promiscuity Index of individual compound, that is, the number of binding targets in the 2-HN for SHU formula.