Table 3: “Hub” herbal compounds identified from the pharmacological subnetwork of the 2-HN for SHU formula.

Name CAS RN PubChem CID PIAction Reference

Quercetin117-39-55280343222(i) Quercetin and rutin exhibit prooxidant effect in healthy and antioxidant activity in influenza—infected animals. [39]
(ii) Quercetin and oseltamivir exhibited antivirus effect on the Toll-like receptor 7 (TLR7) signaling pathway when dendritic cells and macrophages were infected with H1N1. [40]
Resveratrol 501-36-0445154218Resveratrol inhibited the replication of influenza virus in MDCK cells. [43]
Kaempferol520-18-3528086367Kaempferol inhibited influenza A nucleoprotein production in human lung epithelial (A549) cells infected with the H5N1 virus strain A/Thailand/Kan-1/04 in non-toxic concentrations. [44]
Eugenol97-53-0331461Eugenol could inhibit autophagy and influenza A virus replication, inhibit the activation of ERK, p38MAPK and IKK/NF- B signal pathways. [45]

PI is Promiscuity Index of individual compound, that is, the number of binding targets in the 2-HN for SHU formula.