Table 5: Literature-verified pathways related to influenza infection corresponding to four pharmacological units.

ModuleEnriched pathways -value RankReference

1Regulation of G1/S transition (part 2) 1 [56]
Influence of Ras and Rho proteins on G1/S Transition 2
EGFR signaling pathway 3[57]
TGF-beta-dependent induction of EMT via MAPK 5[58]
AKT signaling 7[59]
Brca1 as a transcription regulator 9[60]
Histamine H1 receptor signaling in immune response 10[61]

2Estradiol metabolism (human version) 5 [62]
Estradiol metabolism 7
Estradiol metabolism (rodent version) 8
Benzo[a]pyrene metabolism 9[63]
PGE2 signaling in immune response 10[64]

4Apoptotic TNF-family pathways 1[65]
Role of IAP-proteins in apoptosis 2[66]
FAS signaling cascades 4[67]
Inhibition of angiogenesis by PEDF 8[68]
Granzyme B signaling 9[69]
Ceramides signaling pathway 10[70]

5TGF, WNT, and cytoskeletal remodeling 1[71]
Chemokines and adhesion 2[72]
Cytoskeleton remodeling 3[73]
HMGB1/RAGE signaling pathway 5[74]
HSP60 and HSP70/TLR signaling pathway 9[75]
MIF-mediated glucocorticoid regulation 10[76]

The rank is the order of ascending values of enriched pathways corresponding to each primary pharmacological unit.