Differences of Excess and Deficiency Zheng in Patients with Chronic Hepatitis B by Urinary Metabonomics
Table 5
Differential metabolites in EZ and DZ, respectively, compared to WZ group.
Group
Changed metabolites
VIP
FNDZ/WZ
FNEZ/WZ
AUCROC
EZ
Glycine
2.10
0.025
0.56
0.72
0.632
EZ
Propanoic acid
1.74
0.043
0.75
1.35
0.678
EZ
Ethanimidic acid
1.88
0.039
0.74
1.36
0.671
EZ
Thiomorpholine
2.08
0.021
0.50
0.71
0.588
EZ
Butanedioic acid
2.24
0.007
0.47
0.67
0.601
EZ
L-Threonine
1.64
0.049
0.97
1.34
0.618
EZ
2-Propenamide
1.66
0.03
0.66
0.72
0.672
EZ
L-Phenylalanine
2.11
0.019
0.85
1.42
0.655
EZ
D-Ribose
1.86
0.005
0.74
1.52
0.732
EZ
Ribonic acid
1.70
0.01
0.71
1.47
0.711
EZ
Cyclohexanone
2.03
0.003
0.66
1.55
0.744
EZ
Inositol
1.71
0.014
0.92
1.45
0.649
EZ
Butanedioic acid
1.71
0.011
0.92
1.47
0.65
EZ
D-Gluconic acid
1.93
0.012
0.81
1.41
0.661
EZ
Uric acid
2.45
0.000
1.26
1.90
0.726
EZ
3-(3,4-Dihydroxyphenyl)lactic acid
2.03
0.016
0.80
1.43
0.66
EZ
1H-Indole-3-acetic acid
1.96
0.007
0.70
1.50
0.695
EZ
Gulonic acid
1.62
0.042
0.96
1.35
0.619
EZ
Xylonic acid
2.03
0.01
0.80
1.47
0.697
EZ
Maltose
2.08
0.01
0.47
0.68
0.577
EZ
Galactopyranoside
2.07
0.011
0.49
0.68
0.584
EZ
D-Glucose
2.5
0.001
0.46
0.61
0.617
DZ
Butanoic acid
1.55
0.02
0.52
0.84
0.655
DZ
Glycine
1.53
0.034
0.54
0.80
0.604
DZ
L-Alanine
1.91
0.01
0.50
0.73
0.639
DZ
Thiomorpholine
2.04
0.009
0.50
0.71
0.632
DZ
Butanedioic acid
1.92
0.003
0.47
0.67
0.641
DZ
Propanedioic acid
1.22
0.016
1.12
1.57
0.589
DZ
Cyclohexanecarboxylic acid
1.62
0.007
0.49
0.93
0.695
DZ
D-Ribose
1.51
0.006
1.18
1.22
0.675
DZ
Ribitol
1.42
0.006
1.18
1.22
0.675
DZ
Xylopyranoside
1.23
0.029
0.54
1.15
0.705
DZ
Uric acid
2.39
0.001
1.26
1.90
0.591
DZ
Maltose
1.41
0.034
0.54
0.89
0.646
DZ
D-Xylose
1.76
0.009
0.50
0.88
0.678
DZ
Galactopyranose
1.78
0.009
0.50
0.88
0.678
DZ
Maltose,62
1.71
0.011
0.50
0.82
0.654
DZ
Galactopyranoside
1.69
0.013
0.51
0.88
0.665
DZ
D-Glucose
2.04
0.003
0.46
0.61
0.658
EZ represents excess ZHENG patients group, DZ represents deficiency ZHENG patients group. VIP means the variable importance in the project. value was obtained from Mann-Whitney test (ZHENGs compared to WZ group). FNDZ/WZ or FNDZ/WZ is fold change of mean ranks calculated by the differential metabolites of CHB with excess or deficiency ZHENG/the differential metabolites of CHB without ZHENG. AUCROC means the area under the ROC curve.
