Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses

Table 4

Key interactions of S. baicalensis flavonoids with NA1 active sites.

Flavonoids	Hydrogen bonding	Van der Waals interaction
	Glu277	Ile222, Arg224, Ser246; Glu277, and Tyr347
	Glu119, Arg152; Arg156, and Glu277	Glu119, Val149, Arg152; Arg156, Trp178, Ser179; Arg224, Glu227, Arg371; Tyr347, and Ile427
	Arg118, Asp151; Glu276, and Arg371	Arg118, Val149, Asp151; Ser 246, Tyr 274, Glu276; Arg292, Arg371, and Tyr406
	Arg118, Glu119; Glu227, Glu277; Arg292	Arg118, Glu119, Glu227; Glu277, Arg292, and Arg371; Pro431