Citrus bergamia Risso Elevates Intracellular Ca²⁺ in Human Vascular Endothelial Cells due to Release of Ca²⁺ from Primary Intracellular Stores

Figure 3

Involvement of CICR and IICR on BEO-induced intracellular Ca²⁺ release. Effects of CICR inhibitor, dantrolene (10 μM) on BEO-induced intracellular Ca²⁺ release. Application of dantrolene partially attenuated increase in [Ca²⁺]_i by BEO (the first upper line) (a). Involvement of IICR pathways in BEO-induced intracellular Ca²⁺ release ((b), (c)). Increased [Ca²⁺]_i by BEO was significantly inhibited by inhibitors of PLC (U73122, 10 μM) or IP₃ receptors (2-APB, 10 μM).

(a)

(b)

(c)