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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 760804, 8 pages
http://dx.doi.org/10.1155/2013/760804
Research Article

Beneficial Effects of an 8-Week, Very Low Carbohydrate Diet Intervention on Obese Subjects

Yunjuan Gu,1,2,3,4,5 Haoyong Yu,1,2,3,4 Yuehua Li,4 Xiaojing Ma,1,2,3,4 Junxi Lu,1,2,3,4 Weihui Yu,1,2,3,4 Yunfeng Xiao,4 Yuqian Bao,1,2,3,4 and Weiping Jia1,2,3,4

1Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Centre of Diabetes, Shanghai 200233, China
2Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
3Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
4Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
5Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

Received 31 December 2012; Revised 18 February 2013; Accepted 18 February 2013

Academic Editor: Wei Jia

Copyright © 2013 Yunjuan Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To investigate the effects of weight loss during an 8-week very low carbohydrate diet (VLCD) on improvement of metabolic parameters, adipose distribution and body composition, and insulin resistance and sensitivity in Chinese obese subjects. Methods. Fifty-three healthy obese volunteers were given an 8-week VLCD. The outcomes were changes in anthropometry, body composition, metabolic profile, abdominal fat distribution, liver fat percent (LFP), and insulin resistance and sensitivity. Results. A total of 46 (86.8%) obese subjects completed the study. The VLCD caused a weight loss of  kg (mean ± standard error (SE), ) combined with a significant improvement of metabolic profile. In both male and female, nonesterified fatty acid (NEFA) significantly decreased ( μmol/L, ) and β-hydroxybutyric acid (BHA) increased (  mmol/L, ) after eight weeks of VLCD intervention. The significant reductions in subcutaneous fat area (SFA), visceral fat area (VFA), and LFP were  cm2,  cm2, and %, respectively (all values ). HOMA IR and HOMA β significantly decreased while whole body insulin sensitivity index (WBISI) increased (all values ). Conclusion. Eight weeks of VLCD was an effective intervention in obese subjects. These beneficial effects may be associated with enhanced hepatic and whole-body lipolysis and oxidation.