Unexpected Nephrotoxicity in Male Ablactated Rats Induced by Cordyceps militaris: The Involvement of Oxidative Changes

Table 7

Effects of CCM exposure on antioxidant enzyme activities in kidneys of ablactated rats.

Item	Treatment (g/kg)
	0	1	2	3
Male rats
SOD (U/mg protein)	29.4±6.4	29.3±5.2	26.9±6.2	23.2±5.5^∗
CAT (μmol/min/mg protein)	154.1±21.5	150.2±23.7	149.3±24.7	126.1±22.9^∗
GR (mU/mg protein)	552.1±101.3	550.3±110.6	525.4±112.8	520.2±119.9
GPx (mU/mg protein)	923.6±213.5	880.5±187.9	856.3±198.3	840.9±201.5^∗
GST (mU/mg protein)	0.68±0.15	0.68±0.16	0.69±0.17	0.65±0.18
GSSG/GSH ratio	0.65±0.11	0.64±0.16	0.78±0.12	0.97±0.25^∗
Female rats
SOD (U/mg protein)	35.2±7.1	34.1±6.4	31.2±6.5	28.7±4.4^∗
CAT (μmol/min/mg protein)	143.2±18.3	145.2±21.8	140.5±23.5	136.3±21.3
GR (mU/mg protein)	514.5±121.7	502.2±104.9	497.3±112.2	505.3±124.5
GPx (mU/mg protein)	822.5±194.4	823.4±199.2	801.5±195.7	811.8±215.7
GST (mU/mg protein)	0.54±0.11	0.55±0.12	0.58±0.13	0.54±0.12
GSSG/GSH ratio	0.71±0.10	0.73±0.15	0.79±0.17	0.96±0.21^∗

Each value is expressed as mean ± SD (𝑛=10/sex/dose).
SOD: superoxide dismutase; CAT: catalase; GR: glutathione reductase; GPx: glutathione peroxidase; GST: glutathione S-transferase; GSSG: glutathione oxidized form; GSH: glutathione reduced form.
^∗𝑃<0.05.