Research Article

Postischemic Long-Term Treatment with Qiangli Tianma Duzhong Capsule Improves Brain Functional Recovery via the Improvement of Hemorrheology and the Inhibition of Platelet Aggregation in a Rat Model of Focal Cerebral Ischemia

Figure 3

Post-ischemic long-term treatment with TMDZ improves the histopathological changes after ischemic stroke. Animals underwent 2 h MCAO and reperfusion and received either an oral administration of TMDZ or vehicle (distilled water) at 2 h MCAO, 4 h reperfusion, and every day later for 28 days, and the HE staining was measured 28 days after stroke. Computer generated MosaiX processed images (Carl Zeiss MicroImaging, Inc, Thornwood, NY, USA) of HE paraffin-embedded brain sections at coronal level (bregma  mm) from rats treated with vehicle or treated with TMDZ. The representative images of the entire slice (a), 4x (b), and 20x (c). The vehicle-treated rat (ischemia-reperfusion control group, IR Control) showed typical appearance of cystic necrosis, and pannecrosis involved the entire neocortical thickness, extending to subjacent regions. In contrast, rats treated with TMDZ showed less extensive damage. Values shown are mean ± S.D., . Statistical analysis was carried out with one-way ANOVA followed by a post hoc Tukey test. ## versus sham-operated group (Sham); ** versus ischemia-reperfusion control group (IR Control).
795365.fig.003a
(a)
795365.fig.003b
(b)
795365.fig.003c
(c)
795365.fig.003d
(d)