Postischemic Long-Term Treatment with Qiangli Tianma Duzhong Capsule Improves Brain Functional Recovery via the Improvement of Hemorrheology and the Inhibition of Platelet Aggregation in a Rat Model of Focal Cerebral Ischemia
Figure 5
Post-ischemic long-term treatment with TMDZ improves neurological outcome after ischemic stroke. Animals underwent 2 h MCAO and reperfusion and received either an oral administration of TMDZ or vehicle (distilled water) at 2 h MCAO, 4 h reperfusion, and every day later for 28 days followed by neurological testing at 1, 3, 7, 14, 21, and 28 days. (a) The corner test demonstrated preferential turning to the right in animals that had undergone right MCAO/reperfusion and vehicle administration after stroke. Deficits persisted up to 28 days after stroke. Animals that received TMDZ, however, showed reduction of deficits over time. (b) The cylinder test demonstrated preferential right forearm placement in animals that had undergone right MCAO/reperfusion and vehicle administration after stroke. Deficits persisted up to 28 days after stroke. Animals that received TMDZ, however, showed reduction of deficits over time. Values shown are mean ± S.D., . Statistical analysis was carried out with one-way ANOVA followed by a post hoc Tukey test. ## versus sham-operated group (Sham); ** versus ischemic-reperfusion control group (IR Control).
