Acupuncture-Evoked Response in Somatosensory and Prefrontal Cortices Predicts Immediate Pain Reduction in Carpal Tunnel Syndrome

Table 3

Cortical region significantly correlated with change of pain.

Region	Side	Cluster size	𝑃 value	max_𝑧		MNI (mm)
					𝑋	𝑌	𝑍
Nonflipped analysis
Distal
PFC	R	640	0.00313	−3.36	28	38	20
Verum (local + distal)
SMA	R/L	788	0.00186	−3.79	0	−30	62
PFC	R	987	0.000342	−3.44	32	48	18
PFC	L	625	0.00826	−3.48	−32	26	38
Flipped analysis
Verum (local + distal)
S1	R	198	0.0012	−3.46	32	−26	60

Note: S1: primary somatosensory cortex, SMA: supplementary motor area, PFC: prefrontal cortex. Nonflipped analysis: group map with the original orientation of the data as acquired from the scanner. Flipped analysis: subjects with left-sided lesions had their fMRI data flipped across the midsagittal plane to evaluate brain regions known to be lateralized relative to somatosensory stimulation (i.e., S1, M1, thalamus). Cluster size represents the number of voxels in the cluster. “𝑃 value” represents the cluster probability. “max_𝑧” represents normalized probability. “𝑥, 𝑦, 𝑧” represent the MNI coordinates of the region’s peak voxel from the cluster.