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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 801501, 10 pages
http://dx.doi.org/10.1155/2013/801501
Research Article

Predicting In Silico Which Mixtures of the Natural Products of Plants Might Most Effectively Kill Human Leukemia Cells?

1Faculty of Agriculture Research Park (FARP) and Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12513, Egypt
2Department of Clinical Pathology, National Cancer Institute, Cairo University, Giza 12513, Egypt
3Genomics Core Facility, Department of Plant Soil and Agricultural Systems, SIUC, Carbondale, IL 62901, USA

Received 4 September 2012; Revised 6 December 2012; Accepted 10 December 2012

Academic Editor: Shun-Wan Chan

Copyright © 2013 Hany A. El-Shemy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the analysis of just 13 natural products of plants was to predict the most likely effective artificial mixtures of 2-3 most effective natural products on leukemia cells from over 364 possible mixtures. The natural product selected included resveratrol, honokiol, chrysin, limonene, cholecalciferol, cerulenin, aloe emodin, and salicin and had over 600 potential protein targets. Target profiling used the Ontomine set of tools for literature searches of potential binding proteins, binding constant predictions, binding site predictions, and pathway network pattern analysis. The analyses indicated that 6 of the 13 natural products predicted binding proteins which were important targets for established cancer treatments. Improvements in effectiveness were predicted for artificial combinations of 2 or 3 natural products. That effect might be attributed to drug synergism rather than increased numbers of binding proteins bound (dose effects). Among natural products, the combinations of aloe emodin with mevinolin and honokiol were predicted to be the most effective combination for AML-related predicted binding proteins. Therefore, plant extracts may in future provide more effective medicines than the single purified natural products of modern medicine, in some cases.