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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 801501, 10 pages
http://dx.doi.org/10.1155/2013/801501
Research Article

Predicting In Silico Which Mixtures of the Natural Products of Plants Might Most Effectively Kill Human Leukemia Cells?

1Faculty of Agriculture Research Park (FARP) and Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12513, Egypt
2Department of Clinical Pathology, National Cancer Institute, Cairo University, Giza 12513, Egypt
3Genomics Core Facility, Department of Plant Soil and Agricultural Systems, SIUC, Carbondale, IL 62901, USA

Received 4 September 2012; Revised 6 December 2012; Accepted 10 December 2012

Academic Editor: Shun-Wan Chan

Copyright © 2013 Hany A. El-Shemy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Wink, A. W. Alfermann, R. Franke et al., “Sustainable bioproduction of phytochemicals by plant in vitro cultures: anticancer agents,” Plant Genetic Resources, vol. 3, no. 2, pp. 90–100, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Mishra, B. Zhang, J. M. Cunnick, N. Heisterkamp, and J. Groffen, “Resistance to imatinib of Bcr/Abl P190 lymphoblastic leukemia cells,” Cancer Research, vol. 66, no. 10, pp. 5387–5393, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Mungur, A. D. M. Glass, D. B. Goodenow, and D. A. Lightfoot, “Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene,” Journal of Biomedicine and Biotechnology, vol. 2005, no. 2, pp. 198–214, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. D. J. Barlow, A. Buriani, T. Ehrman, E. Bosisio, I. Eberini, and P. J. Hylands, “In-silico studies in Chinese herbal medicines’ research: evaluation of in-silico methodologies and phytochemical data sources, and a review of research to date,” Journal of Ethnopharmacology, vol. 140, pp. 526–534, 2012.
  5. H. Sheridan, L. Krenn, R. Jiang et al., “The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations,” Journal of Ethnopharmacology, vol. 140, pp. 482–491, 2012.
  6. X. Chen, Z. J. Zhan, X. W. Zhang, J. Ding, and J. M. Yue, “Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis,” Planta Medica, vol. 71, no. 10, pp. 949–954, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. A. El-Shemy, A. M. Aboul-Enein, K. M. Aboul-Enein, and K. Fujita, “Willow leaves' extracts contain anti-tumor agents effective against three cell types,” PLoS ONE, vol. 2, no. 1, article e178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Cervantes, F. Passamonti, and G. Barosi, “Life expectancy and prognostic factors in the classic BCR/ABL-negative myeloproliferative disorders,” Leukemia, vol. 22, no. 5, pp. 905–914, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. H. A. El-Shemy, M. A. M. Aboul-Soud, A. A. Nassr-Allah, K. M. Aboul-Enein, A. Kabash, and A. Yagi, “Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction,” Current Medicinal Chemistry, vol. 17, no. 2, pp. 129–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Campillos, M. Kuhn, A. C. Gavin, L. J. Jensen, and P. Bork, “Drug target identification using side-effect similarity,” Science, vol. 321, no. 5886, pp. 263–266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Gao, Y. X. Xu, G. Divine, N. Janakiraman, R. A. Chapman, and S. C. Gautam, “Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes,” Journal of Nutrition, vol. 132, no. 7, pp. 2076–2081, 2002. View at Scopus
  12. A. D. Kinghorn, E. J. Carcache de Blanco, H.-B Chai, et al., “Discovery of anticancer agents of diverse natural origins,” Pure and Applied Chemistry, vol. 81, no. 1051, 1063 pages, 2009.
  13. J. H. Won, J. S. Park, H. H. Ju, S. Kim, H. Suh-Kim, and S. H. Ghil, “The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions,” Cellular Signalling, vol. 20, no. 5, pp. 884–891, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Fazlina, A. Maha, A. L. Zarina et al., “Assessment of P-gp and MRP1 activities using MultiDrugQuant Assay Kit: a preliminary study of correlation between protein expressions and its functional activities in newly diagnosed acute leukaemia patients,” The Malaysian Journal of Pathology, vol. 30, no. 2, pp. 87–93, 2008. View at Scopus
  15. M. S. Brassesco, A. P. Montaldi, D. E. Gras et al., “Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors,” Mutagenesis, vol. 24, no. 2, pp. 153–160, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Buchert, C. Darido, E. Lagerqvist et al., “The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1,” Gastroenterology, vol. 137, no. 1, pp. 156–164, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Yamasaki, T. Nakamura, N. Okamura et al., “Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells,” European Journal of Pharmaceutical Sciences, vol. 37, no. 2, pp. 126–132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Nabekura, T. Yamaki, and S. Kitagawa, “Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1,” European Journal of Pharmacology, vol. 600, no. 1–3, pp. 45–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Bobrowska-Hägerstrand, M. Lillås, L. Mrówczyñska et al., “Resveratrol oligomers are potent MRP1 transport inhibitors,” Anticancer Research, vol. 26, no. 3, pp. 2081–2084, 2006. View at Scopus
  20. R. Zhao, T. J. Raub, G. A. Sawada et al., “Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier,” Drug Metabolism and Disposition, vol. 37, no. 6, pp. 1251–1258, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Niitsu, Y. Hayashi, and Y. Honma, “Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13),” Oncogene, vol. 20, no. 3, pp. 375–384, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Gao, H. Li, H. Zhang et al., “PDTD: a web-accessible protein database for drug target identification,” BMC Bioinformatics, vol. 9, article 104, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. D. L. Stirewalt, S. Meshinchi, K. J. Kopecky et al., “Identification of genes with abnormal expression changes in acute myeloid leukemia,” Genes Chromosomes and Cancer, vol. 47, no. 1, pp. 8–20, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Majeti, M. W. Becker, Q. Tian et al., “Dysregulated gene expression networks in human acute myelogenous leukemia stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 9, pp. 3396–3401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Nacu, R. Critchley-Thorne, P. Lee, and S. Holmes, “Gene expression network analysis and applications to immunology,” Bioinformatics, vol. 23, no. 7, pp. 850–858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. A. El-Shemy, A. M. Aboul-Enein, M. I. Aboul-Enein, S. I. Issa, and K. Fujita, “The effect of willow leaf extracts on human leukemic cells in vitro,” Journal of Biochemistry and Molecular Biology, vol. 36, no. 4, pp. 387–389, 2003. View at Scopus
  27. D. Calzolari, S. Bruschi, L. Coquin et al., “Search algorithms as a framework for the optimization of drug combinations,” PLoS Computational Biology, vol. 4, no. 12, Article ID e1000249, 2008. View at Publisher · View at Google Scholar · View at Scopus