Research Article
Combination Therapy of Sophoraflavanone B against MRSA: In Vitro Synergy Testing
Table 3
Results of the combination of SPF-B + AMP against MRSA.
| S. aureus | Agent | MIC (μg/mL) | FIC | FICI | Outcome | Alone | SPF-B + AMP |
| ATCC 33591 | SPF-B | 15.6 | 3.9 | 0.25 | 0.75 | Partial synergy | AMP | 500 | 250 | 0.5 | DPS-1 | SPF-B | 15.6 | 3.9 | 0.25 | 0.75 | Partial synergy | AMP | 250 | 125 | 0.5 | DPS-2 | SPF-B | 31.25 | 3.9 | 0.12 | 0.62 | Partial synergy | AMP | 125 | 62.5 | 0.5 | DPS-3 | SPF-B | 31.25 | 15.6 | 0.5 | 0.62 | Partial synergy | AMP | 250 | 31.25 | 0.12 | DPS-4 | SPF-B | 31.25 | 15.6 | 0.5 | 0.53 | Partial synergy | AMP | 62.5 | 1.95 | 0.03 | DPS-5 | SPF-B | 31.25 | 7.8 | 0.25 | 0.75 | Partial synergy | AMP | 62.5 | 31.25 | 0.5 |
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