About this Journal Submit a Manuscript Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 828143, 15 pages
http://dx.doi.org/10.1155/2013/828143
Research Article

Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells

1Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
2Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan
3Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4Department of Beauty Science, National Taichung University of Science and Technology, Taichung 403, Taiwan
5School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan
6Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
8Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

Received 12 September 2012; Revised 28 December 2012; Accepted 23 January 2013

Academic Editor: Seung-Heon Hong

Copyright © 2013 Jen-Yu Hung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Demicheli, M. Fornili, F. Ambrogi et al., “Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases,” Journal of Thoracic Oncology, vol. 7, pp. 723–730, 2012.
  2. R. Siegel, E. Ward, O. Brawley, and A. Jemal, “Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths,” CA: A Cancer Journal for Clinicians, vol. 61, pp. 212–236, 2011.
  3. M. Provencio, A. Sánchez, P. Garrido, and F. Valcárcel, “New molecular targeted therapies integrated with radiation therapy in lung cancer,” Clinical Lung Cancer, vol. 11, pp. 91–97, 2010.
  4. K. Shiozaki, M. Shiozaki, and P. Russell, “Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade,” Molecular Biology of the Cell, vol. 8, no. 3, pp. 409–419, 1997. View at Scopus
  5. H. Vakifahmetoglu, M. Olsson, and B. Zhivotovsky, “Death through a tragedy: mitotic catastrophe,” Cell Death and Differentiation, vol. 15, no. 7, pp. 1153–1162, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Castedo, J. L. Perfettini, T. Roumier, K. Andreau, R. Medema, and G. Kroemer, “Cell death by mitotic catastrophe: a molecular definition,” Oncogene, vol. 23, no. 16, pp. 2825–2837, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Galluzzi, I. Vitale, J. M. Abrams, et al., “Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death,” Cell Death Differ, vol. 19, pp. 107–120, 2012.
  8. Y. W. Eom, M. A. Kim, S. S. Park et al., “Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype,” Oncogene, vol. 24, no. 30, pp. 4765–4777, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. R. J. Vasquez, B. Howell, A. M. C. Yvon, P. Wadsworth, and L. Cassimeris, “Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro,” Molecular Biology of the Cell, vol. 8, no. 6, pp. 973–985, 1997. View at Scopus
  10. T. F. Burns, P. Fei, K. A. Scata, D. T. Dicker, and W. S. El-Deiry, “Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (Taxol)-exposed cells,” Molecular and Cellular Biology, vol. 23, no. 16, pp. 5556–5571, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Galluzzi, I. Vitale, E. Vacchelli, and G. Kroemer, “Cell death signaling and anticancer therapy,” Frontiers in Oncology, vol. 5, no. 1, 2011.
  12. L. Formentini, M. Sánchez-Aragó, L. Sánchez-Cenizo, and J. M. Cuezva, “The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response,” Molecular Cell, vol. 45, pp. 731–742, 2012.
  13. D. Gnocchi, S. Leoni, S. Incerpi, and G. Bruscalupi, “3,5,3-triiodothyronine (T3) stimulates cell proliferation through the activation of the PI3K/Akt pathway and reactive oxygen species (ROS) production in chick embryo hepatocytes,” Steroids, vol. 77, pp. 589–595, 2012.
  14. J. Y. Hung, Y. L. Hsu, W. C. Ni et al., “Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells,” Lung Cancer, vol. 68, no. 3, pp. 355–365, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. H. Han and W. H. Park, “The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione,” Oncology Reports, vol. 22, no. 2, pp. 385–391, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Lenaz, “Mitochondria and reactive oxygen species. Which role in physiology and pathology?” Advances in Experimental Medicine and Biology, vol. 942, pp. 93–136, 2012.
  17. P. L. Kuo, C. Y. Chen, and Y. L. Hsu, “Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells,” Cancer Research, vol. 67, no. 15, pp. 7406–7420, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. L. F. Dong, P. Low, J. C. Dyason et al., “α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II,” Oncogene, vol. 27, no. 31, pp. 4324–4335, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Makovski, E. Yaffe, S. Shpungin, and U. Nir, “Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells,” Cell Signal, vol. 24, pp. 1369–1374, 2012.
  20. J. Huang, J. Yang, B. Maity, D. Mayuzumi, and R. A. Fisher, “Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism,” Cancer Research, vol. 71, pp. 6310–6319, 2011.
  21. C. H. Lee, C. N. Kuo, H. L. Chen, and C. Y. Chen, “Review on pharmacological activities of Cinnamomum subavenium,” Natural Product Research, 2012.
  22. H. M. Wang, C. C. Chiu, P. F. Wu, and C. Y. Chen, “Subamolide e from Cinnamomum subavenium induces sub-G1 cell-cycle arrest and caspase-dependent apoptosis and reduces the migration ability of human melanoma cells,” Journal of Agricultural and Food Chemistry, vol. 59, no. 15, pp. 8187–8192, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. C. H. Liu, C. Y. Chen, A. M. Huang, and J. H. Li, “Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1,” Journal of Ethnopharmacology, vol. 137, pp. 503–511, 2011.
  24. J. E. Purvis, K. W. Karhohs, C. Mock, E. Batchelor, A. Loewer, and G. Lahav, “p53 dynamics control cell fate,” Science, vol. 336, pp. 1440–1444, 2012.
  25. A. Okamoto, Y. Iwamoto, and Y. Maru, “Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy,” Molecular and Cellular Biology, vol. 26, no. 3, pp. 1087–1097, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Taketani, J. Kawauchi, M. Tanaka-Okamoto et al., “Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells,” Oncogene, vol. 31, pp. 2210–2221, 2012.
  27. A. Chang, “Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC,” Lung Cancer, vol. 71, no. 1, pp. 3–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Vitale, L. Galluzzi, M. Castedo, and G. Kroemer, “Mitotic catastrophe: a mechanism for avoiding genomic instability,” Nature Reviews Molecular Cell Biology, vol. 12, pp. 385–392, 2011.
  29. D. Huertas, M. Soler, J. Moreto et al., “Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin,” Oncogene, vol. 31, pp. 1408–1418, 2012.
  30. L. Jiang, M. K. Siu, O. G. Wong et al., “iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe,” Clinical Cancer Research, vol. 17, pp. 6924–6933, 2011.
  31. M. Nitta, O. Kobayashi, S. Honda et al., “Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents,” Oncogene, vol. 23, no. 39, pp. 6548–6558, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Cerna, H. Li, S. Flaherty, N. Takebe, C. N. Coleman, and S. S. Yoo, “Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner,” Journal of Biological Chemistry, vol. 287, pp. 22408–22417, 2012.
  33. S. Piccirillo, G. Filomeni, B. Brüne, G. Rotilio, and M. R. Ciriolo, “Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in adenocarcinoma cells,” Journal of Biological Chemistry, vol. 284, no. 40, pp. 27721–27733, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Kigawa, Y. Minagawa, X. Cheng, and N. Terakawa, “γ-glutamyl cysteine synthetase up-regulates glutathione and multidrug resistance-associated protein in patients with chemoresistant epithelial ovarian cancer,” Clinical Cancer Research, vol. 4, no. 7, pp. 1737–1741, 1998. View at Scopus
  35. M. Tamada, O. Nagano, S. Tateyama et al., “Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells,” Cancer Research, vol. 72, pp. 1438–1448, 2012.
  36. N. Berdelle, T. Nikolova, S. Quiros, T. Efferth, and B. Kaina, “Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells,” Molecular Cancer Therapeutics, vol. 10, pp. 2224–2233, 2011.
  37. G. Imreh, H. V. Norberg, S. Imreh, and B. Zhivotovsky, “Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis,” Journal of Cell Science, vol. 124, pp. 2951–2963, 2011.
  38. H. Zhao, F. Traganos, and Z. Darzynkiewicz, “Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation,” Cell Cycle, vol. 7, no. 19, pp. 3048–3055, 2008. View at Scopus
  39. K. C. Das and R. Dashnamoorthy, “Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites,” American Journal of Physiology, vol. 286, no. 1, pp. L87–L97, 2004. View at Scopus
  40. A. P. Gonçalves, V. Máximo, J. Lima, K. K. Singh, P. Soares, and A. Videira, “Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone,” Biochimica et Biophysica Acta, vol. 1813, no. 3, pp. 492–499, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. B. P. C. Chen, C. D. Wolfgang, and T. Hai, “Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10,” Molecular and Cellular Biology, vol. 16, no. 3, pp. 1157–1168, 1996. View at Scopus
  42. M. Gilchrist, W. R. Henderson Jr., A. Morotti et al., “A key role for ATF3 in regulating mast cell survival and mediator release,” Blood, vol. 115, no. 23, pp. 4734–4741, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. O. Kwon, N. K. Soung, N. R. Thimmegowda et al., “Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation,” Cell Signal, vol. 24, pp. 943–950, 2012.
  44. E. N. Gurzov, J. Barthson, I. Marhfour et al., “Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation,” Oncogene, vol. 31, pp. 1723–1732, 2012.
  45. S. Bandyopadhyay, Y. Wang, R. Zhan et al., “The tumor metastasis suppressor gene Drg-1down-regulates the expression of activating transcription factor 3 in prostate cancer,” Cancer Research, vol. 66, pp. 11983–11990, 2006.
  46. C. S. Germain, N. Niknejad, L. Ma, K. Garbui, T. Hai, and J. Dimitroulakos, “Cisplatin induces cytotoxicity through the mitogen-activated protein kinase pathways and activating transcription factor 3,” Neoplasia, vol. 12, no. 7, pp. 527–538, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. H. Wang, P. Mo, S. Ren, and C. Yan, “Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6,” Journal of Biological Chemistry, vol. 285, no. 17, pp. 13201–13210, 2010. View at Publisher · View at Google Scholar · View at Scopus