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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 836179, 8 pages
http://dx.doi.org/10.1155/2013/836179
Research Article

A Metabolomics-Based Strategy for the Quality Control of Traditional Chinese Medicine: Shengmai Injection as a Case Study

1College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, China
2Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA

Received 6 December 2012; Accepted 19 December 2012

Academic Editor: Aiping Lu

Copyright © 2013 Xiaodong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Gilbert, Chinese Herbal Medicine Breaks into EU Market, 2012.
  2. G. B. Mahady, H. S. Fong, and N. R. Farnsworth, Botanical Dietary Supplements: Quality, Safety, and Efficacy, Swets & Zeitlinger, Amsterdam, The Netherlands, 2001.
  3. X. Di, K. K. C. Chan, H. W. Leung, and C. W. Huie, “Fingerprint profiling of acid hydrolyzates of polysaccharides extracted from the fruiting bodies and spores of Lingzhi by high-performance thin-layer chromatography,” Journal of Chromatography A, vol. 1018, no. 1, pp. 85–95, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. FDA Guidance for Industry—Botanical Drug Products (Draft Guidance), US Food and Drug Administration, Rockville, Md, USA, 2000.
  5. Note for Guidance on Quality, of Herbal Medicinal Products, European Medicines Agency, London, UK, 2001.
  6. P. S. Xie, “A feasible strategy for applying chromatography fingerprint to assess quality of Chinese herbal medicine,” in Proceedings of the International Symposium on Quality of TCM with Chromatographic Fingerprint, Guangzhou, China, 2001.
  7. R. Capasso, A. A. Izzo, L. Pinto, T. Bifulco, C. Vitobello, and N. Mascolo, “Phytotherapy and quality of herbal medicines,” Fitoterapia, vol. 71, no. 1, pp. S58–S65, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. L. W. Yang, D. H. Wu, X. Tang et al., “Fingerprint quality control of Tianjihuang by high-performance liquid chromatography-photodiode array detection,” Journal of Chromatography A, vol. 1070, no. 1-2, pp. 35–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. O. Sticher, “Quality of Ginkgo preparations,” Planta Medica, vol. 59, no. 1, pp. 2–11, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. WHO, Guidelines for the Assessment of Herbal Medicines, World Health Organization, Munich, Germany, 1991.
  11. State Food and Drug Administration of China, Note for Studying Fingerprint of Traditional Chinese Medicine Injections (Draft), Shanghai, China, 2000.
  12. O. Fiehn, “Metabolomics—the link between genotypes and phenotypes,” Plant Molecular Biology, vol. 48, no. 1-2, pp. 155–171, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Rochfort, “Metabolomics reviewed: a new “omics” platform technology for systems biology and implications for natural products research,” Journal of Natural Products, vol. 68, no. 12, pp. 1813–1820, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Lan and W. Jia, “An Integrated metabolomics and pharmacokinetics strategy for multi-component drugs evaluation,” Current Drug Metabolism, vol. 11, no. 1, pp. 105–114, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. E. C. Y. Chan, S. L. Yap, A. J. Lau, P. C. Leow, D. F. Toh, and H. L. Koh, “Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng,” Rapid Communications in Mass Spectrometry, vol. 21, no. 4, pp. 519–528, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. J. L. Wolfender, G. Glauser, J. Boccard, and S. Rudaz, “MS-based plant metabolomic approaches for biomarker discovery,” Natural Product Communications, vol. 4, no. 10, pp. 1417–1430, 2009. View at Scopus
  17. G. Xie, R. Plumb, M. Su et al., “Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research,” Journal of Separation Science, vol. 31, no. 6-7, pp. 1015–1026, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Dai, C. Xiao, H. Liu, and H. Tang, “Combined NMR and LC-MS analysis reveals the metabonomic changes in salvia miltiorrhiza bunge induced by water depletion,” Journal of Proteome Research, vol. 9, no. 3, pp. 1460–1475, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Dai, C. Xiao, H. Liu, F. Hao, and H. Tang, “Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of salvia miltiorrhiza bunge,” Journal of Proteome Research, vol. 9, no. 3, pp. 1565–1578, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. X. Liang, X. Chen, Q. Liang et al., “Metabonomic study of Chinese Medicine Shuanglong Formula as an effective treatment for myocardial infarction in rats,” Journal of Proteome Research, vol. 10, no. 2, pp. 790–799, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. H. M. Zhang, S. L. Li, H. Zhang, et al., “Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach,” Journal of Pharmaceutical and Biomedical Analysis, vol. 62, pp. 258–273, 2012.
  22. Traditional Chinese Drug standards of Ministry of Health of the People's Republic of China, Shengmai Zhusheye (Injection) Quality Standard, Ministry of Health, Beijing, China, 1998.
  23. J. E. Jackson, A Users Guide to Principal Components, Wiley, New York, NY, USA, 1991.
  24. L. Eriksson, E. Johansson, N. Kettaneh-Wold, and S. Wold, Multi- and Megavariate Data Analysis, Umetrics Academy, Umea, Sweden, 2001.
  25. S. S. Zeng, L. Wang, T. Chen, et al., “Direct analysis in real time mass spectrometry and multivariate data analysis: a novel approach to rapid identification of analytical markers for quality control of traditional Chinese medicine preparation,” Analytica Chimica Acta, vol. 733, pp. 38–47, 2012.