Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity
Figure 2
EGb inhibited NF-κB activation in CDDP-induced acute renal injury in rats. ((a)–(e)) Immunohistochemical detection of translocational phospho-p65 NF-κB in renal tissues. (a) Control, (b) EGb, (c) CDDP, and (d) CDDP + EGb. In EGb + CDDP group, nuclear stainings (grown) in renal tubular cells were significantly reduced compared with CDDP treated group. Magnification, ×100. (e) The number of NF-κB activated cells was summarized. (f) Phospho-p65 and p65 expressions in nuclear and cytosolic protein extracts from CDDP-injected rats were analyzed by western blotting. Data represent mean ± S.D. from three independent experiments. versus saline; versus CDDP.
