Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide

Table 1

Effect of andrographolide on mortality of acute pulmonary thrombosis caused by intravenous injection of ADP in experimental mice.

	Total no.; of mice	Number of; deaths	Mortality; rate (%)
Solvent control (0.5 DMSO)	6	0	0
ADP (700 mg/kg)	10	9	90
ADP (700 mg/kg) +
andrographolide (μg, kg)
22	10	6	60*
55	10	5	50*

ADP: adenosine diphosphate; DMSO: dimethyl sulfoxide.
^∗𝑃<0.05 (compared with ADP control).