Review Article
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide
Table 2
Dosage and toxicity of Andrographis paniculata and its major natural product andrographolide.
| Products name | Dosage/duration/route | Experimental models | Toxic effects | References |
| Andrographolide | 10 mg/kg for 3 weeks | Human | No | [3] | Andrographolide | 500 mg/kg bw for 7 days i.p. | Mice | No | [4] | Andrographolide | 25–75 μM | Platelets | No cytotoxicity | [15] | A. paniculata | 20 mg/kg bw for 60 days, oral | Rats | No | [71] | Andrographolide | 22–55 μg/kg, i.v. | Mice | Lower mortality | [97] | A. paniculata | 1 g/kg/day for 4, 6, and 8 weeks | Rats | No | [120] | Andrographolide | 100 mg/kg, i.p. | Mice | No | [121] | Andrographolide | 10 mg/kg, i.v. | Rats | No | [123] |
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i.p.: intraperitoneal; i.v.: intravenous; and bw: body weight.
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