Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
Figure 1
Effects of paclitaxel (PTX) and Goshajinkigan (GJG) on the growth of 4T1 cells in mice. The 4T1 cells were inoculated into the right abdominal mammary fat pad on day 0. (a) Typical example of tumor growth in the mouse breast. ((b), (c)) Time-course of the effects of PTX on the tumor growth (b) with or (c) without GJG administration. PTX (10 and 20 mg/kg) and vehicle (VH1) were injected intraperitoneally every other day from day 7 after tumor cell inoculation. GJG (1 g/kg) and vehicle (VH2) were administered orally every day from day 2 after tumor cell inoculation. Values represent the means ± SEM. Figures in parentheses indicate the number of animals. (b) Interaction between PTX treatment and time, , (two-way repeated measures ANOVA). (c) Interaction between PTX treatment and time, , (two-way repeated measures ANOVA).
