A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo

Table 1

Effect of cinobufagin on spleen and thymus indexes in the experimental group mice.

Group	Spleen index (mg/g)	Thymus index (mg/g)
Control	4.72±0.88	3.53±0.66
Model	3.56±0.48^#	2.80±0.56^#
Cinobufagin	5.67±0.90^#∗∗	4.10±0.75^∗∗
Cinobufagin + NAL-M	4.86±1.07^∗	3.42±0.50^∗
Morphine	4.07±0.76	299±0.58

Control: control group; model: model group; cinobufagin group: cinobufagin, 10 mL/kg/day; cinobufagin + NAL-M group: cinobufagin, 10 mL/kg/day, NAL-M, 20 mg/kg/day; E; morphine group (morphine, 8 mg/kg/day, i.p.). Data are shown as the mean ± SD (𝑛=12). ^#𝑃<0.05, ^##𝑃<0.01 compared to control group; ^∗𝑃<0.05, ^∗∗𝑃<0.01 compared to model group.