Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells

Figure 1

t-BHP treatment induced changes of senescence-associated features in WI38 cells. WI38 cells at early passage were treated by t-BHP to induce premature senescence; then SA β-gal staining (a), DAPI staining (b), cell proliferation assay (c), or Western blot assay using specific antibodies (d) were performed in early passage cells (E), t-BHP-induced premature senescent cells (t), and replicative senescent cells (L), respectively. Data were presented as mean ± SD of three independent experiments. ^∗∗𝑃<0.01 compared with control group.

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