Water Extract of Dryopteris crassirhizoma Attenuates Bone Loss by Suppressing Osteoclast Differentiation and Function

Figure 6

WEDC attenuates RANKL-induced bone loss in mice. 8-week-old mice were orally administrated with WEDC (0.25 g/kg) twice a day for 5 days, and RANKL (1 mg/kg) were intraperitoneally injected on days 3 and 4. The femora were collected on day 6 and analyzed by micro-CT scanning. (a) Representative micro-CT images of the distal femora. (b) Trabecular bone volume/tissue volume (BV/TV), trabecular number (Tb. N), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp) at the distal femoral metaphysis. Data are expressed as mean ± SD. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001.

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