Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid

Table 3

The width and weight/length ratio (mg/cm) of the distal colons of rats that received rectal TNBS (to induce colitis) or saline solution (S) after treatment for 5 or 12 days with propolis hydroalcoholic solution (TNBS-P and SP) or mesalazine solution (TNBS-M). The animals were euthanized 7 or 14 days after the colitis was induced. The results are expressed as the mean ± standard deviation (𝑛=5).

Group/time (days)	Width (cm)		Weight/length ratio (mg/cm)
	Day 7	Day 14	Day 7	Day 14
S	1.02±0.18^a	1.00±0.07^a	252.4±61.1^a	268.0±42.6^a
TNBS	1.56±0.31^b	1.36±0.15^a	558.2±46.4^b	415.1±105.9^a
SP	1.02±0.18^a	1.04±0.19^a	236.7±41.6^a	259.8±18.0^a
TNBS-P	1.26±0.18^a	1.25±0.18^a	500.7±125.3^bc	687.3±169.0^c
TNBS-M	1.16±0.15^a	1.25±0.11^a	423.2±90.6^c	605.9±67.1^c

^a,b,cThe means followed by different letters in the same column are significantly different according to a one-way ANOVA model and Tukey’s post-test (𝑃<0.05).