Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice

Table 2

Effect of the essential oil of Hyptis martiusii (EOHM, 100 and 500 mg/kg) on hematological parameters in male and female Swiss mice treated orally for 30 days.

Parameter	Control		EOHM 100 mg/kg		EOHM 500 mg/kg
	Male	Female	Male	Female	Male	Female
Erythrocytes (10^6/µL)	9.59±0.18	9.90±0.10	9.40±0.58	9.69±0.17	8.96±0.57	10.02±0.17
Hemoglobin (g/dL)	16.40±0.48	16.71±0.33	16.51±0.68	16.89±0.15	14.64±1.28	17.50±0.22
Hematocrit (%)	45.34±1.15	46.61±0.28	44.26±2.61	46.43±0.45	40.06±2.96	47.16±0.90
MCV (fL)	47.71±0.28	48.11±1.03	47.57±0.36	48.29±0.35	45.43±0.86^∗	47.71±0.52
MCH (pg)	17.21±0.09	17.24±0.09	17.14±0.25	17.44±0.17	16.27±0.54	17.30±0.15
MCHC (g/dL)	36.17±0.22	36.60±0.10	36.60±0.28	36.33±0.14	35.93±0.58	36.74±0.10
RDW (%)	18.17±0.48	15.53±0.29	17.19±0.40	15.47±0.21	18.76±1.08	15.59±0.34
WBC (10^3/µL)	10.70±1.03	12.36±1.55	14.41±1.26	11.70±1.21	14.83±2.04	13.67±1.26
Platelets (10^3/µL)	1061.00±98.70	872.60±17.88	839.50±91.68	761.70±31.97	1140.00±58.77	975.30±73.71
MPV (fL)	6.07±0.12	5.82±0.13	6.00±0.13	5.71±0.09	6.31±0.18	5.71±0.09
Lymphocytes (%)	92.59±0.70	94.53±0.43	91.41±0.64	92.83±0.46	91.33±0.80	92.89±0.80
Monocytes (%)	0.87±0.08	0.52±0.06	0.75±0.13	0.58±0.09	1.61±0.48	0.50±0.06
Neutrophils (%)	6.32±0.60	4.58±0.41	7.05±0.40	5.21±0.46	6.45±0.30	5.25±0.64
Eosinophils (%)	0.05±0.02	0	0.04±0.02	0.05±0.02	0.04±0.04	0.04±0.02
Basophils (%)	0.43±0.06	0.35±0.08	0.50±0.03	0.45±0.03	0.53±0.16	0.41±0.05

MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, RDW: red cell distribution width, WBC: white blood cell, and MPV: mean platelet volume. Values represent the mean ± S.E.M (𝑛=10/group). *Statistically different from the control group (ANOVA followed by Dunnett's test, 𝑃<0.05).