Induction of Apoptosis and Cell Cycle Blockade by Helichrysetin in A549 Human Lung Adenocarcinoma Cells
Figure 1
(a) Structure of helichrysetin. (b) HT-29, A549, MCF-7, and Ca Ski cells were treated with different concentrations of helichrysetin for up to 72 hours, and the percentage of inhibition was evaluated using MTT assay. The results are shown as mean ± S.E. and was regarded as statistically significant compared to the untreated control. The percentage of inhibition in untreated control was normalized to 0%. (c) DAPI staining on untreated A549 cells (left) and helichrysetin-treated A549 cells (right) at 40x magnification. Nuclear fragmentation is indicated by bright blue cells (arrow).
