Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro

Figure 2

Effects of LPRP-9 on PI3 K/AKT/FaxO and MAPK pathways. Cells were treated with indicated doses of doxorubicin or LPRP-9 for 24 h. (a) Immunoblots results showing AKT activation status by detecting phosphorylation of AKT Thr³⁰⁸, Ser⁴⁷³, and FaxO3a Ser^318/321 in MCF-7 (left) and Huh-7 (right) cells. (b) Immunoblots results showing MAPK activation status by detecting phosphorylation of ERK1/2 Thr²⁰²/Tyr²⁰⁴, JNK Thr¹⁸³/Tyr¹⁸⁵, and p38α/β Thr¹⁸⁰/Tyr¹⁸² in MCF-7 (left) and Huh-7 (right) cells.

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